› 5m9v

X-ray diffraction
1.7Å resolution

Human angiogenin PD/ALS variant R121C

Released:
DOI: 10.2210/pdb5m9v/pdb
PDB entry 5m9v coloured by chain, front view.
PDB entry 5m9v coloured by chain, side view.
PDB entry 5m9v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Bradshaw WJ, Rehman S, Pham TT, Thiyagarajan N, Lee RL, Subramanian V, Acharya KR
OpenAccess logo Sci Rep 7 41996 (2017)
PMID: 28176817

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiogenin Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03950 (Residues: 25-147; Coverage: 100%)
Gene names: ANG, RNASE5
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

2 bound ligands:
Ligand TLA 1 x TLA
Ligand GSH 1 x GSH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2221
Unit cell:
a: 82.539Å b: 118.969Å c: 37.409Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.209 0.239
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Motor Neuron Susceptibility in ALS/FTD.
Ragagnin et al. (2019)
8 more

1 mention without citation

Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Bradshaw et al. (2017)