› 5mcx

Electron Microscopy
6.8Å resolution

The structure of the mature HIV-1 CA hexamer in intact virus particles

Released:
DOI: 10.2210/pdb5mcx/pdb
PDB entry 5mcx coloured by chain, front view.
PDB entry 5mcx coloured by chain, side view.
PDB entry 5mcx coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
The structure and flexibility of conical HIV-1 capsids determined within intact virions.
Mattei S, Glass B, Hagen WJ, Kräusslich HG, Briggs JA
Science 354 1434-1437 (2016)
PMID: 27980210
Related structures: EMD-3465

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110321 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gag protein Chains: A, B, C, D, E, F, G, I, J, K, L, N, O, P, Q, R, S, U, V, W, Y, Z, b, c
Molecule details ›
Chains: A, B, C, D, E, F, G, I, J, K, L, N, O, P, Q, R, S, U, V, W, Y, Z, b, c
Length: 221 amino acids
Theoretical weight: 24.65 KDa
Source organism: Human immunodeficiency virus 1
UniProt:
  • Canonical: B6DRA0 (Residues: 133-353; Coverage: 55%)
Gene name: gag
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.8Å
Relevant EMDB volumes: EMD-3465

Quick links

Citations

55 review citations

Restriction of HIV-1 and other retroviruses by TRIM5.
Ganser-Pornillos et al. (2019)
54 more

10 mentions without citation

Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle.
Novikova et al. (2019)
9 more