› 5mgf

X-ray diffraction
1.9Å resolution

Crystal Structure of BAZ2B bromodomain in complex with 4-propionyl-pyrrole derivative 2

Released:
DOI: 10.2210/pdb5mgf/pdb
PDB entry 5mgf coloured by chain, front view.
PDB entry 5mgf coloured by chain, side view.
PDB entry 5mgf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of BAZ2A bromodomain ligands.
Spiliotopoulos D, Wamhoff EC, Lolli G, Rademacher C, Caflisch A
Eur J Med Chem 139 564-572 (2017)
PMID: 28837921

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193783 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain adjacent to zinc finger domain protein 2B Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UIF8 (Residues: 2054-2167; Coverage: 5%)
Gene names: BAZ2B, KIAA1476
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand 7MW 1 x 7MW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: C2221
Unit cell:
a: 81.118Å b: 96.103Å c: 57.48Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.177 0.201
Expression system: Escherichia coli

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Citations

1 review citation

Targeting bromodomain-containing proteins: research advances of drug discovery.
Pan et al. (2023)
8 other articles