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Crystal structure of dCK mutant C3S in complex with masitinib and UDP

Source organism: Homo sapiens
Biochemical function: cytidine kinase activity
Biological process: nucleoside phosphate biosynthetic process
Cellular component: cytosol

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EC 2.7.1.76: Deoxyadenosine kinase

Reaction catalysed:
ATP + deoxyadenosine = ADP + dAMP
Systematic name:
ATP:deoxyadenosine 5'-phosphotransferase
Alternative Name(s):
  • Deoxyadenosine kinase (phosphorylating)
  • Purine-deoxyribonucleoside kinase

EC 2.7.1.74: Deoxycytidine kinase

Reaction catalysed:
NTP + deoxycytidine = NDP + dCMP
Systematic name:
NTP:deoxycytidine 5'-phosphotransferase
Alternative Name(s):
  • 2'-deoxycytidine kinase
  • Ara-C kinase
  • Arabinofuranosylcytosine kinase
  • Deoxycytidine kinase (phosphorylating)
  • Deoxycytidine-cytidine kinase

EC 2.7.1.113: Deoxyguanosine kinase

Reaction catalysed:
ATP + deoxyguanosine = ADP + dGMP
Systematic name:
ATP:deoxyguanosine 5'-phosphotransferase
Alternative Name(s):
  • (Dihydroxypropoxymethyl)guanine kinase
  • 2'-deoxyguanosine kinase
  • Deoxyguanosine kinase (phosphorylating)
  • NTP-deoxyguanosine 5'-phosphotransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01712
Domain description: Deoxynucleoside kinase
Occurring in:
  1. Deoxycytidine kinase
The deposited structure of PDB entry 5mql contains 4 copies of Pfam domain PF01712 (Deoxynucleoside kinase) in Deoxycytidine kinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR031314
Domain description: Deoxynucleoside kinase domain
Occurring in:
  1. Deoxycytidine kinase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Deoxycytidine kinase
IPR002624
Domain description: Deoxynucleoside kinase
Occurring in:
  1. Deoxycytidine kinase
IPR012349
Domain description: FMN-binding split barrel
Occurring in:
  1. Deoxycytidine kinase

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Deoxycytidine kinase
The deposited structure of PDB entry 5mql contains 4 copies of CATH domain 3.40.50.300 (Rossmann fold) in Deoxycytidine kinase. Showing 1 copy in chain A.

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