› 5mvm

X-ray diffraction
3.1Å resolution

X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol

Released:
DOI: 10.2210/pdb5mvm/pdb
PDB entry 5mvm coloured by chain, front view.
PDB entry 5mvm coloured by chain, side view.
PDB entry 5mvm coloured by chain, top view.
Source organism: Gloeobacter violaceus PCC 7421
Entry authors: Fourati Z, Delarue M

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181806 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proton-gated ion channel Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 317 amino acids
Theoretical weight: 36.16 KDa
Source organism: Gloeobacter violaceus PCC 7421
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7NDN8 (Residues: 43-359; Coverage: 100%)
Gene names: glr4197, glvI
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains:

Ligands and Environments

6 bound ligands:
Ligand LMT 6 x LMT
Ligand ACT 10 x ACT
Ligand CL 5 x CL
Ligand NA 7 x NA
Ligand PLC 15 x PLC
Ligand PFL 5 x PFL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: C2
Unit cell:
a: 181.76Å b: 132.51Å c: 160.52Å
α: 90° β: 102.72° γ: 90°
R-values:
R R work R free
0.196 0.195 0.208
Expression system: Escherichia coli

Quick links