› 5mx0

X-ray diffraction
2.21Å resolution

Crystal structure of human fibromodulin

Released:
DOI: 10.2210/pdb5mx0/pdb
PDB entry 5mx0 coloured by chain, front view.
PDB entry 5mx0 coloured by chain, side view.
PDB entry 5mx0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin.
Paracuellos P, Kalamajski S, Bonna A, Bihan D, Farndale RW, Hohenester E
OpenAccess logo Matrix Biol 63 106-116 (2017)
PMID: 28215822

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170399 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Fibromodulin Chains: A, B
Molecule details ›
Chains: A, B
Length: 362 amino acids
Theoretical weight: 40.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q06828 (Residues: 18-376; Coverage: 100%)
Gene names: FM, FMOD, SLRR2E
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
2 bound ligands:
Ligand CL 2 x CL
Ligand NI 2 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 108.11Å b: 98.93Å c: 111.34Å
α: 90° β: 107.39° γ: 90°
R-values:
R R work R free
0.181 0.179 0.216
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Cartilage diseases.
Krishnan et al. (2018)
3 more

10 mentions without citation

Sequence features, structure, ligand interaction, and diseases in small leucine rich repeat proteoglycans.
Matsushima et al. (2021)
9 more