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Crystal structure of the Arp4-N-actin(ATP-state) heterodimer bound by a nanobody

Source organisms:
Biochemical function: ATP binding
Biological process: regulation of DNA-templated transcription
Cellular component: intracellular non-membrane-bounded organelle

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00022
Domain description: Actin
Occurring in:
  1. Actin-related protein 4
  2. Actin
The deposited structure of PDB entry 5nbm contains 2 copies of Pfam domain PF00022 (Actin) in Actin-related protein 4. Showing 1 copy in chain A.
The deposited structure of PDB entry 5nbm contains 2 copies of Pfam domain PF00022 (Actin) in Actin. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR004000
Domain description: Actin family
Occurring in:
  1. Actin-related protein 4
  2. Actin
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Actin-related protein 4
  2. Actin
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. nAct-Nanobody
IPR004001
Domain description: Actin, conserved site
Occurring in:
  1. Actin
IPR020902
Domain description: Actin/actin-like conserved site
Occurring in:
  1. Actin-related protein 4
  2. Actin
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. nAct-Nanobody
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. nAct-Nanobody
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. nAct-Nanobody
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. nAct-Nanobody

Structure domains

CATH CATH domains
3.30.420.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Actin-related protein 4
  2. Actin
The deposited structure of PDB entry 5nbm contains 4 copies of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Actin-related protein 4. Showing 2 copies in chain A.
The deposited structure of PDB entry 5nbm contains 4 copies of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Actin. Showing 2 copies in chain C.
3.90.640.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Actin; Chain A, domain 4
Homology: Actin; Chain A, domain 4
Occurring in:
  1. Actin-related protein 4
  2. Actin
The deposited structure of PDB entry 5nbm contains 2 copies of CATH domain 3.90.640.10 (Actin; Chain A, domain 4) in Actin-related protein 4. Showing 1 copy in chain A.
The deposited structure of PDB entry 5nbm contains 2 copies of CATH domain 3.90.640.10 (Actin; Chain A, domain 4) in Actin. Showing 1 copy in chain C.

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