GO terms
Biochemical function:
Biological process:
- negative regulation of forebrain neuron differentiation
- positive regulation of cellular senescence
- amyloid fibril formation
- positive regulation of transferrin receptor binding
- positive regulation of ferrous iron binding
- positive regulation of receptor binding
- negative regulation of receptor binding
- cellular response to nicotine
- cellular response to iron(III) ion
- cellular response to iron ion
- multicellular organismal-level iron ion homeostasis
- protein homotetramerization
- positive regulation of T cell activation
- positive regulation of immune response
- negative regulation of neurogenesis
- negative regulation of epithelial cell proliferation
- positive regulation of receptor-mediated endocytosis
- regulation of erythrocyte differentiation
- protein refolding
- regulation of iron ion transport
- T cell differentiation in thymus
- positive regulation of protein binding
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- antigen processing and presentation of endogenous peptide antigen via MHC class I
- negative regulation of neuron projection development
- learning or memory
- sensory perception of smell
- immune response
- intracellular iron ion homeostasis
- iron ion transport
- positive regulation of T cell cytokine production
- peptide antigen assembly with MHC class II protein complex
- peptide antigen assembly with MHC class I protein complex
- antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
- antigen processing and presentation of peptide antigen via MHC class I
- response to molecule of bacterial origin
- positive regulation of T cell mediated cytotoxicity
- T cell mediated cytotoxicity
- adaptive immune response
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR003006
Domain description:
Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
Occurring in:
Structure domains
CATH domains
2.60.40.10
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Immunoglobulin-like
Homology:
Immunoglobulins
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>5nht</span> contains 1 copy of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>HLA class I histocompatibility antigen, A alpha chain</span>. Showing 1 copy in chain <span class='highlight'>A [auth H]</span>. The deposited structure of PDB entry 5nht contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/5nht_1_H_CATH_2.60.40.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>5nht</span> contains 1 copy of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>Beta-2-microglobulin</span>. Showing 1 copy in chain <span class='highlight'>B [auth L]</span>. The deposited structure of PDB entry 5nht contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Beta-2-microglobulin. Showing 1 copy in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/5nht_2_L_CATH_2.60.40.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>5nht</span> contains 2 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>Ig-like domain-containing protein</span>. Showing 2 copies in chain <span class='highlight'>D [auth A]</span>. The deposited structure of PDB entry 5nht contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig-like domain-containing protein. Showing 2 copies in chain D [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/5nht_4_A_CATH_2.60.40.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>5nht</span> contains 2 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>Ig-like domain-containing protein</span>. Showing 2 copies in chain <span class='highlight'>E [auth B]</span>. The deposited structure of PDB entry 5nht contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig-like domain-containing protein. Showing 2 copies in chain E [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/5nht_5_B_CATH_2.60.40.10_image-200x200.png)