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Structure of an ABC transporter: complete structure

Source organisms:
Biochemical function: ABC-type transporter activity
Biological process: xenobiotic transport across blood-brain barrier
Cellular component: external side of apical plasma membrane

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EC 7.6.2.2: ABC-type xenobiotic transporter

Reaction catalysed:
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
Alternative Name(s):
  • ATP phosphohydrolase (steroid-exporting)
  • MDR protein
  • Multidrug-resistance protein
  • P-glycoprotein
  • PDR protein
  • Pleiotropic-drug-resistance protein
  • Steroid-transporting ATPase
  • Xenobiotic-transporting ATPase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF01061
Domain description: ABC-2 type transporter
Occurring in:
  1. Broad substrate specificity ATP-binding cassette transporter ABCG2
The deposited structure of PDB entry 5nj3 contains 2 copies of Pfam domain PF01061 (ABC-2 type transporter) in Broad substrate specificity ATP-binding cassette transporter ABCG2. Showing 1 copy in chain A.

PF19055
Domain description: ABC-2 type transporter
Occurring in:
  1. Broad substrate specificity ATP-binding cassette transporter ABCG2
The deposited structure of PDB entry 5nj3 contains 2 copies of Pfam domain PF19055 (ABC-2 type transporter) in Broad substrate specificity ATP-binding cassette transporter ABCG2. Showing 1 copy in chain A.

PF00005
Domain description: ABC transporter
Occurring in:
  1. Broad substrate specificity ATP-binding cassette transporter ABCG2
The deposited structure of PDB entry 5nj3 contains 2 copies of Pfam domain PF00005 (ABC transporter) in Broad substrate specificity ATP-binding cassette transporter ABCG2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. 5D3-Fab heavy chain
  2. 5D3-Fab light chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. 5D3-Fab heavy chain
  2. 5D3-Fab light chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. 5D3-Fab heavy chain
  2. 5D3-Fab light chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. 5D3-Fab heavy chain
  2. 5D3-Fab light chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. 5D3-Fab heavy chain
  2. 5D3-Fab light chain
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. 5D3-Fab heavy chain
  2. 5D3-Fab light chain
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Broad substrate specificity ATP-binding cassette transporter ABCG2
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. Broad substrate specificity ATP-binding cassette transporter ABCG2
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. 5D3-Fab light chain
IPR013525
Domain description: ABC-2 type transporter, transmembrane domain
Occurring in:
  1. Broad substrate specificity ATP-binding cassette transporter ABCG2
IPR043926
Domain description: ABC transporter family G domain
Occurring in:
  1. Broad substrate specificity ATP-binding cassette transporter ABCG2
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Broad substrate specificity ATP-binding cassette transporter ABCG2

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. 5D3-Fab heavy chain
  2. 5D3-Fab light chain
The deposited structure of PDB entry 5nj3 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in 5D3-Fab heavy chain. Showing 1 copy in chain C.
The deposited structure of PDB entry 5nj3 contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in 5D3-Fab light chain. Showing 2 copies in chain D.

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