› 5nm2

X-ray diffraction
1.95Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine receptor A2a; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 433 amino acids
Theoretical weight: 48 KDa
Source organisms: Expression system: Trichoplusia ni
UniProt:
  • Canonical: P29274 (Residues: 2-208, 219-317; Coverage: 74%)
  • Canonical: P0ABE7 (Residues: 23-127; Coverage: 99%)
Gene names: ADORA2, ADORA2A, cybC
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand NA 1 x NA
Ligand ZMA 1 x ZMA
Ligand OLA 15 x OLA
Ligand OLB 2 x OLB
Ligand OLC 2 x OLC
Ligand CLR 3 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2221
Unit cell:
a: 39.428Å b: 179.599Å c: 139.847Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.175 0.212
Expression system: Trichoplusia ni

Quick links

Citations

13 review citations

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.
Wold et al. (2019)
12 more

15 mentions without citation

Exploring G Protein-Coupled Receptors (GPCRs) Ligand Space via Cheminformatics Approaches: Impact on Rational Drug Design.
Basith et al. (2018)
14 more