› 5nni

X-ray diffraction
3.21Å resolution

Dimer structure of Sortilin ectodomain crystal form 2, 3.2 Angstrom

Released:
DOI: 10.2210/pdb5nni/pdb
PDB entry 5nni coloured by chain, front view.
PDB entry 5nni coloured by chain, side view.
PDB entry 5nni coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.
Leloup N, Lössl P, Meijer DH, Brennich M, Heck AJR, Thies-Weesie DME, Janssen BJC
OpenAccess logo Nat Commun 8 1708 (2017)
PMID: 29167428

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180157 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Sortilin Chains: A, B
Molecule details ›
Chains: A, B
Length: 732 amino acids
Theoretical weight: 81.36 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PHU5 (Residues: 31-753; Coverage: 91%)
  • Best match: Q6PHU5-2 (Residues: 31-751)
Gene name: Sort1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 79.842Å b: 137.17Å c: 147.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.227 0.255
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Structural Perspectives on Extracellular Recognition and Conformational Changes of Several Type-I Transmembrane Receptors.
Chataigner et al. (2020)
3 more

1 mention without citation

Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.
Leloup et al. (2017)