› 5np7

Electron Microscopy
4.2Å resolution

CryoEM structure of Human Rad51 on single-stranded DNA to 4.2A resolution.

Released:
DOI: 10.2210/pdb5np7/pdb
PDB entry 5np7 coloured by chain, front view.
PDB entry 5np7 coloured by chain, side view.
PDB entry 5np7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy.
Short JM, Liu Y, Chen S, Soni N, Madhusudhan MS, Shivji MK, Venkitaraman AR
OpenAccess logo Nucleic Acids Res 44 9017-9030 (2016)
PMID: 27596592
Related structures: EMD-8183

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-554882 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA repair protein RAD51 homolog 1 Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 339 amino acids
Theoretical weight: 37.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06609 (Residues: 1-339; Coverage: 100%)
Gene names: RAD51, RAD51A, RECA
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ANP 7 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-8183
Expression system: Escherichia coli

Quick links

Citations

15 review citations

RAD51 Gene Family Structure and Function.
Bonilla et al. (2020)
14 more

3 mentions without citation

Fanconi anemia pathway as a prospective target for cancer intervention.
Liu et al. (2020)
2 more