› 5npz

X-ray diffraction
1.43Å resolution

Porcine (Sus scrofa) Major Histocompatibility Complex, class I, presenting EFEDLTFLA

Released:
DOI: 10.2210/pdb5npz/pdb
Model geometry
Fit model/data
PDB entry 5npz coloured by chain, front view.
PDB entry 5npz coloured by chain, side view.
PDB entry 5npz coloured by chain, top view.
Source organisms:
Primary publication:
Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.
Tungatt K, Dolton G, Morgan SB, Attaf M, Fuller A, Whalley T, Hemmink JD, Porter E, Szomolay B, Montoya M, Hammond JA, Miles JJ, Cole DK, Townsend A, Bailey M, Rizkallah PJ, Charleston B, Tchilian E, Sewell AK
OpenAccess logo PLoS Pathog 14 e1007017 (2018)
PMID: 29772011

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-109392 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.78 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: B1PJV3 (Residues: 22-297; Coverage: 81%)
Gene name: SLA-1
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.56 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07717 (Residues: 21-118; Coverage: 100%)
Gene name: B2M
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Nucleoprotein Chain: C

Ligands and Environments

3 bound ligands:
Ligand EDO 5 x EDO
Ligand GOL 2 x GOL
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 42.034Å b: 128.29Å c: 46.794Å
α: 90° β: 101.9° γ: 90°
R-values:
R R work R free
0.186 0.184 0.214
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

7 review citations

Rethinking next-generation vaccines for coronaviruses, influenzaviruses, and other respiratory viruses.
Morens et al. (2023)
6 more

2 mentions without citation

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.
Tungatt et al. (2018)
1 more