Function and Biology Details
Reaction catalysed:
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero decamer (preferred)
Assembly name:
Complement factor H complex (preferred)
PDBe Complex ID:
PDB-CPX-133854 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (7 distinct):
Complement C3 beta chain
Molecule details ›
Chains: A, E
Length: 645 amino acids
Theoretical weight: 71.39 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 645 amino acids
Theoretical weight: 71.39 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P01024 (Residues: 23-667; Coverage: 39%)
Sequence domains:
Complement C3b alpha' chain
Molecule details ›
Chains: B, F
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P01024 (Residues: 749-1663; Coverage: 56%)
Sequence domains:
Complement factor H
Complement factor I heavy chain
Complement factor I light chain
Ligands and Environments
Experiments and Validation Details
wwPDB Validation report is not available for this entry.
X-ray source:
ESRF BEAMLINE ID23-1
Spacegroup:
P1
Expression system: Homo sapiens
