EC 2.7.11.1: Non-specific serine/threonine protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
- A-kinase
- AP50 kinase
- ATP-protein transphosphorylase
- Beta-IIPKC
- Beta-adrenergic receptor kinase
- CK-2
- CKI
- CKII
- Calcium-dependent protein kinase C
- Calcium/phospholipid-dependent protein kinase
- Casein kinase
- Casein kinase (phosphorylating)
- Casein kinase 2
- Casein kinase I
- Casein kinase II
- Cyclic AMP-dependent protein kinase
- Cyclic AMP-dependent protein kinase A
- Cyclic monophosphate-dependent protein kinase
- Cyclic nucleotide-dependent protein kinase
- Cyclin-dependent kinase
- Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
- Dsk1
- Epsilon PKC
- Glycogen synthase A kinase
- Glycogen synthase a kinase
- Glycogen synthase kinase
- HIPK2
- Hpr kinase
- Hydroxyalkyl-protein kinase
- M phase-specific cdc2 kinase
- MAPK
- Mitogen-activated S6 kinase
- Mitogen-activated protein kinase
- P82 kinase
- PKA
- PKC
- Phosphorylase B kinase kinase
- Phosphorylase b kinase kinase
- Phosphorylase b kinase kinase
- Protein glutamyl kinase
- Protein kinase (phosphorylating)
- Protein kinase A
- Protein kinase CK2
- Protein kinase p58
- Protein phosphokinase
- Protein serine kinase
- Protein serine-threonine kinase
- Protein-aspartyl kinase
- Protein-cysteine kinase
- Protein-serine kinase
- Prp4 protein kinase
- Raf kinase
- Raf-1
- Ribosomal S6 protein kinase
- Ribosomal protein S6 kinase II
- STK32
- Serine kinase
- Serine protein kinase
- Serine(threonine) protein kinase
- Serine-specific protein kinase
- Serine/threonine protein kinase
- T-antigen kinase
- Threonine-specific protein kinase
- Twitchin kinase
- Type-2 casein kinase
- WEE1Hu
- Wee 1-like kinase
- Wee-kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase A
- cGMP-dependent protein kinase
EC 3.6.5.2: Small monomeric GTPase
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)
GO terms
Biochemical function:
- guanyl-nucleotide exchange factor activity
- Rho GDP-dissociation inhibitor binding
- protein-containing complex binding
- thioesterase binding
- GTP-dependent protein binding
- protein kinase binding
- enzyme binding
- hydrolase activity
- GTP binding
- protein binding
- G protein activity
- GTPase activity
- nucleotide binding
Biological process:
- regulation of neuron migration
- positive regulation of ovarian follicle development
- midbrain dopaminergic neuron differentiation
- interneuron migration
- positive regulation of skeletal muscle acetylcholine-gated channel clustering
- positive regulation of bicellular tight junction assembly
- regulation of neutrophil migration
- regulation of synaptic vesicle endocytosis
- positive regulation of ruffle assembly
- positive regulation of substrate adhesion-dependent cell spreading
- regulation of postsynapse assembly
- ruffle assembly
- cochlea morphogenesis
- positive regulation of neutrophil chemotaxis
- angiotensin-activated signaling pathway involved in heart process
- protein localization to plasma membrane
- dopaminergic neuron differentiation
- semaphorin-plexin signaling pathway
- regulation of ERK5 cascade
- regulation of cell adhesion involved in heart morphogenesis
- positive regulation of dendritic spine development
- cell chemotaxis
- regulation of respiratory burst
- Wnt signaling pathway, planar cell polarity pathway
- synaptic transmission, GABAergic
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- positive regulation of focal adhesion assembly
- localization within membrane
- positive regulation of stress fiber assembly
- regulation of stress fiber assembly
- homeostasis of number of cells within a tissue
- cell motility
- dendrite morphogenesis
- neuron projection morphogenesis
- anatomical structure arrangement
- negative regulation of receptor-mediated endocytosis
- regulation of neuronal synaptic plasticity
- hepatocyte growth factor receptor signaling pathway
- regulation of receptor signaling pathway via JAK-STAT
- respiratory burst
- regulation of nitric oxide biosynthetic process
- cell-cell junction organization
- engulfment of apoptotic cell
- erythrocyte enucleation
- superoxide anion generation
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- non-canonical Wnt signaling pathway
- intracellular signal transduction
- positive regulation of Rho protein signal transduction
- substrate adhesion-dependent cell spreading
- regulation of actin cytoskeleton organization
- negative regulation of interleukin-23 production
- response to lipopolysaccharide
- ruffle organization
- positive regulation of microtubule polymerization
- forebrain development
- cortical cytoskeleton organization
- positive regulation of actin filament polymerization
- regulation of cell migration
- actin filament polymerization
- actin cytoskeleton organization
- lamellipodium assembly
- cell projection assembly
- regulation of cell morphogenesis
- cerebral cortex GABAergic interneuron development
- embryonic olfactory bulb interneuron precursor migration
- cerebral cortex radially oriented cell migration
- Rac protein signal transduction
- cell migration
- dendrite development
- regulation of neuron maturation
- positive regulation of cell-substrate adhesion
- negative regulation of fibroblast migration
- regulation of fibroblast migration
- positive regulation of endothelial cell migration
- positive regulation of lamellipodium assembly
- regulation of lamellipodium assembly
- regulation of hydrogen peroxide metabolic process
- anatomical structure morphogenesis
- response to wounding
- regulation of cell size
- regulation of cell shape
- motor neuron axon guidance
- axon guidance
- small GTPase-mediated signal transduction
- G protein-coupled receptor signaling pathway
- enzyme-linked receptor protein signaling pathway
- establishment or maintenance of cell polarity
- cell-matrix adhesion
- cell adhesion
- actin filament organization
- cytoskeleton organization
- hyperosmotic response
- inflammatory response
- phagocytosis, engulfment
- endocytosis
- epithelial cell morphogenesis
- sphingosine-1-phosphate receptor signaling pathway
- auditory receptor cell morphogenesis
- positive regulation of protein phosphorylation
- neuron migration
Cellular component:
- ficolin-1-rich granule membrane
- glutamatergic synapse
- postsynapse
- extracellular exosome
- kinocilium
- recycling endosome membrane
- postsynaptic membrane
- synapse
- NADPH oxidase complex
- cell projection
- presynaptic membrane
- melanosome
- cytoplasmic ribonucleoprotein granule
- ruffle membrane
- early endosome membrane
- cytoplasmic vesicle
- synaptic vesicle membrane
- secretory granule membrane
- dendrite
- lamellipodium
- membrane
- cell cortex
- focal adhesion
- plasma membrane
- actin filament
- cytoskeleton
- cytosol
- trans-Golgi network
- endoplasmic reticulum membrane
- cytoplasm
- nucleus
- phagocytic cup
- pericentriolar material
Sequence families
Protein families (Pfam)
InterPro annotationsStructure domains
CATH domains
1.20.900.10
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Dbl Homology Domain; Chain A
Homology:
Dbl homology (DH) domain
Occurring in:
