› 5o4f

X-ray diffraction
2.1Å resolution

Structure of GluK3 ligand-binding domain (S1S2) in complex with the agonist LM-12b at 2.10 A resolution

Released:
DOI: 10.2210/pdb5o4f/pdb
PDB entry 5o4f coloured by chain, front view.
PDB entry 5o4f coloured by chain, side view.
PDB entry 5o4f coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.
Møllerud S, Pinto A, Marconi L, Frydenvang K, Thorsen TS, Laulumaa S, Venskutonytė R, Winther S, Moral AMC, Tamborini L, Conti P, Pickering DS, Kastrup JS
ACS Chem Neurosci 8 2056-2064 (2017)
PMID: 28691798

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154591 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.09 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P42264 (Residues: 432-546, 669-806; Coverage: 29%)
Gene names: Glur7, Grik3
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

5 bound ligands:
Ligand GOL 5 x GOL
Ligand 8VE 2 x 8VE
Ligand ZN 6 x ZN
Ligand CL 5 x CL
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P2221
Unit cell:
a: 131.392Å b: 56.205Å c: 87.462Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.192 0.215
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
2 more