› 5odb

X-ray diffraction
1.53Å resolution

Crystal structure of the RA-associated mAb D10 (chimeric Fab fragment)

Released:
DOI: 10.2210/pdb5odb/pdb
Model geometry
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PDB entry 5odb coloured by chain, front view.
PDB entry 5odb coloured by chain, side view.
PDB entry 5odb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Ge C, Xu B, Liang B, Lönnblom E, Lundström SL, Zubarev RA, Ayoglu B, Nilsson P, Skogh T, Kastbom A, Malmström V, Klareskog L, Toes REM, Rispens T, Dobritzsch D, Holmdahl R
Arthritis Rheumatol 71 210-221 (2019)
PMID: 30152126

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213868 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
D10 Fab fragment - heavy chain Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
D10 Fab fragment - light chain Chain: B
Molecule details ›
Chain: B
Length: 213 amino acids
Theoretical weight: 23.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 47.368Å b: 66.714Å c: 72.764Å
α: 90° β: 93.85° γ: 90°
R-values:
R R work R free
0.189 0.188 0.214
Expression system: Homo sapiens

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Citations

12 review citations

Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology.
Volkov et al. (2020)
11 more

1 mention without citation

Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis.
Fichtner et al. (2020)

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