PDB 5odc structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reactions catalysed:

CoB + CoM + methanophenazine = CoM-S-S-CoB + dihydromethanophenazine

H(2) + NAD(+) = H(+) + NADH

H(2) + A = AH(2)

Biochemical function:

oxidoreductase activity

Biological process:

methanogenesis

Cellular component:

plasma membrane

Sequence domains:

7 more domains

Structure analysis Details

Assembly composition:

hetero dodecamer (preferred)

PDBe Complex ID:

PDB-CPX-104160 (preferred)

Entry contents:

6 distinct polypeptide molecules

Macromolecules (6 distinct):

CoB--CoM heterodisulfide reductase iron-sulfur subunit A Chains: A, G

Molecule details ›

Chains: A, G
Length: 654 amino acids
Theoretical weight: 71.59 KDa
Source organism: Methanothermococcus thermolithotrophicus DSM 2095
UniProt:

Canonical: A0A2D0TCB9 (Residues: 1-654; Coverage: 100%)

Sequence domains:

Cysteine-rich domain-containing protein Chains: B, H

Molecule details ›

Chains: B, H
Length: 291 amino acids
Theoretical weight: 32.08 KDa
Source organism: Methanothermococcus thermolithotrophicus DSM 2095
UniProt:

Canonical: A0A2D0TCB4 (Residues: 1-291; Coverage: 100%)

Sequence domains: Cysteine-rich domain

4Fe-4S ferredoxin-type domain-containing protein Chains: C, I

Molecule details ›

Chains: C, I
Length: 184 amino acids
Theoretical weight: 20.48 KDa
Source organism: Methanothermococcus thermolithotrophicus DSM 2095
UniProt:

Canonical: A0A2D0TC97 (Residues: 1-184; Coverage: 100%)

Sequence domains: 4Fe-4S dicluster domain

F420-non-reducing hydrogenase iron-sulfur subunit D domain-containing protein Chains: D, J

Molecule details ›

Chains: D, J
Length: 140 amino acids
Theoretical weight: 16.06 KDa
Source organism: Methanothermococcus thermolithotrophicus DSM 2095
UniProt:

Canonical: A0A2D0TC98 (Residues: 1-140; Coverage: 100%)

Sequence domains: Methyl-viologen-reducing hydrogenase, delta subunit

NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein Chains: E, K

Molecule details ›

Chains: E, K
Length: 299 amino acids
Theoretical weight: 32.51 KDa
Source organism: Methanothermococcus thermolithotrophicus DSM 2095
UniProt:

Canonical: A0A2D0TC99 (Residues: 1-299; Coverage: 100%)

Sequence domains: NADH ubiquinone oxidoreductase, 20 Kd subunit

Methyl-viologen reducing hydrogenase, subunit A Chains: F, L

Molecule details ›

Chains: F, L
Length: 473 amino acids
Theoretical weight: 53.13 KDa
Source organism: Methanothermococcus thermolithotrophicus DSM 2095
UniProt: