› 5ogq

X-ray diffraction
1.91Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185320 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase C1A papain C-terminal domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 254 amino acids
Theoretical weight: 28.51 KDa
Source organism: Schistosoma mansoni
Expression system: Pichia
UniProt:
  • Canonical: Q8MNY2 (Residues: 87-340; Coverage: 79%)
Gene name: cb1.1
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

2 bound ligands:
Ligand 9U8 3 x 9U8
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P31
Unit cell:
a: 82.39Å b: 82.39Å c: 99.39Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.168 0.167 0.186
Expression system: Pichia

Quick links

Citations

5 review citations

A comprehensive and critical overview of schistosomiasis vaccine candidates.
Al-Naseri et al. (2021)
4 more

2 mentions without citation

Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.
Jílková et al. (2021)
1 more