› 5ova

X-ray diffraction
2.3Å resolution

Apo PDZ domain from rat Shank3

Released:
DOI: 10.2210/pdb5ova/pdb
PDB entry 5ova coloured by chain, front view.
PDB entry 5ova coloured by chain, side view.
PDB entry 5ova coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3.
Ponna SK, Ruskamo S, Myllykoski M, Keller C, Boeckers TM, Kursula P
J Neurochem 145 449-463 (2018)
PMID: 29473168

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191643 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH3 and multiple ankyrin repeat domains protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 96 amino acids
Theoretical weight: 10.4 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JLU4 (Residues: 570-664; Coverage: 6%)
Gene names: Prosap2, Shank3
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 45.08Å b: 48.53Å c: 78.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.281 0.279 0.297
Expression system: Escherichia coli

Quick links

Citations

5 review citations

PDZ Domains as Drug Targets.
Christensen et al. (2019)
4 more

1 mention without citation

Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses.
Bucher et al. (2021)