› 5qie

X-ray diffraction
1.34Å resolution

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of HAO1 in complex with Z2856434894

Released:
DOI: 10.2210/pdb5qie/pdb
PDB entry 5qie coloured by chain, front view.
PDB entry 5qie coloured by chain, side view.
PDB entry 5qie coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: MacKinnon S, Bezerra GA, Krojer T, Bradley AR, Talon R, Brandao-Neto J, Douangamath A, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Oppermann U, Brennan PE, Yue WW

Function and Biology Details

Reactions catalysed: 
(S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2)
Glyoxylate + H(2)O + O(2) = oxalate + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-577486 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2-Hydroxyacid oxidase 1 Chain: A
Molecule details ›
Chain: A
Length: 369 amino acids
Theoretical weight: 40.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UJM8 (Residues: 1-368; Coverage: 100%)
Gene names: GOX1, HAO1
Sequence domains: FMN-dependent dehydrogenase
Structure domains: Aldolase class I

Ligands and Environments


Cofactor: Ligand FMN 1 x FMN
1 bound ligand:
Ligand GWV 1 x GWV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: I4
Unit cell:
a: 97.677Å b: 97.677Å c: 80.414Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.165 0.193
Expression system: Escherichia coli

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