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PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with FMOCR000171b

Source organism: Homo sapiens
Biochemical function: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Biological process: deadenylation-dependent decapping of nuclear-transcribed mRNA
Cellular component: not assigned

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EC 3.6.1.62: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase

Reaction catalysed:
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O = N(7)-methylguanosine 5'-diphosphate + 5'-phospho-[mRNA]
Systematic name:
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] N(7)-methylguanosine-5'-diphosphate phosphohydrolase
Alternative Name(s):
  • D10 decapping enzyme
  • D10 protein
  • D9 protein
  • Dcp2
  • Decapping enzyme
  • M(7)GpppN-mRNA hydrolase
  • M(7)GpppN-mRNA m(7)GDP phosphohydrolase
  • NUDT16

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00293
Domain description: NUDIX domain
Occurring in:
  1. m7GpppN-mRNA hydrolase
The deposited structure of PDB entry 5qoj contains 1 copy of Pfam domain PF00293 (NUDIX domain) in m7GpppN-mRNA hydrolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000086
Domain description: NUDIX hydrolase domain
Occurring in:
  1. m7GpppN-mRNA hydrolase
IPR020084
Domain description: NUDIX hydrolase, conserved site
Occurring in:
  1. m7GpppN-mRNA hydrolase
IPR015797
Domain description: NUDIX hydrolase-like domain superfamily
Occurring in:
  1. m7GpppN-mRNA hydrolase
IPR044099
Domain description: mRNA decapping enzyme 2 , NUDIX hydrolase domain
Occurring in:
  1. m7GpppN-mRNA hydrolase

Structure domain

CATH CATH domain
3.90.79.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Nucleoside Triphosphate Pyrophosphohydrolase
Homology: Nucleoside Triphosphate Pyrophosphohydrolase
Occurring in:
  1. m7GpppN-mRNA hydrolase
The deposited structure of PDB entry 5qoj contains 1 copy of CATH domain 3.90.79.10 (Nucleoside Triphosphate Pyrophosphohydrolase) in m7GpppN-mRNA hydrolase. Showing 1 copy in chain A.

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