› 5rw0

X-ray diffraction
1.67Å resolution

PanDDA analysis group deposition -- Crystal Structure of DHTKD1 in complex with Z2444997446

Released:
DOI: 10.2210/pdb5rw0/pdb
PDB entry 5rw0 coloured by chain, front view.
PDB entry 5rw0 coloured by chain, side view.
PDB entry 5rw0 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bezerra GA, Foster WR, Bailey HJ, Shrestha L, Krojer T, Brandao-Neto J, Douangamath A, Burgess-Brown N, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Yue WW

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188539 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2-oxoadipate dehydrogenase complex component E1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 898 amino acids
Theoretical weight: 100.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96HY7 (Residues: 45-919; Coverage: 95%)
Gene names: DHTKD1, KIAA1630
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand WGD 5 x WGD
Ligand TPP 2 x TPP
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 78.13Å b: 147.127Å c: 87.273Å
α: 90° β: 102.91° γ: 90°
R-values:
R R work R free
0.162 0.161 0.187
Expression system: Escherichia coli

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