› › Function and Biology

INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z915492990

Source organism: Homo sapiens
Biochemical function: phosphatase activity
Biological process: phosphatidylinositol dephosphorylation
Cellular component: not assigned

Quick links

EC 3.1.3.56: Inositol-polyphosphate 5-phosphatase

Reaction catalysed:
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
Systematic name:
1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase
Alternative Name(s):
  • 5PTase
  • D-myo-inositol 1,4,5-triphosphate 5-phosphatase
  • D-myo-inositol 1,4,5-trisphosphate 5-phosphatase
  • D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase
  • Inosine triphosphatase
  • Inositol 1,4,5-trisphosphate phosphatase
  • Inositol phosphate 5-phosphomonoesterase
  • Inositol polyphosphate-5-phosphatase
  • Inositol trisphosphate phosphomonoesterase
  • Inositol-1,4,5-trisphosphate 5-phosphatase
  • Inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase
  • Ins(1,4,5)P(3) 5-phosphatase
  • Ins(1,4,5)P(3)/Ins(1,3,4,5)P(4) 5-phosphatase
  • InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase
  • L-myo-inositol 1,4,5-trisphosphate-monoesterase
  • Myo-inositol-1,4,5-trisphosphate 5-phosphatase
  • Type I inositol-polyphosphate phosphatase

EC 3.1.3.86: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Reaction catalysed:
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate
Systematic name:
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
Alternative Name(s):
  • P150Ship
  • SHIP
  • SHIP1
  • SHIP2

EC 3.1.3.36: Phosphoinositide 5-phosphatase

Reaction catalysed:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
Systematic name:
Phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Alternative Name(s):
  • Diphosphoinositide phosphatase
  • IP(3) phosphatase
  • Inositol 1,4,5-triphosphate 5-phosphomonoesterase
  • Inositol triphosphate 5-phosphomonoesterase
  • Phosphatidyl-inositol-bisphosphate phosphatase
  • Phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase
  • Phosphatidylinositol 4,5-bisphosphate phosphatase
  • Phosphatidylinositol-bisphosphatase
  • Polyphosphoinositol lipid 5-phosphatase
  • PtdIns(4,5)P(2) phosphatase
  • Triphosphoinositide phosphatase
  • Triphosphoinositide phosphomonoesterase
  • Type II inositol polyphosphate 5-phosphatase
  • Type II inositol-1,4,5-trisphosphate 5-phosphatase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF22669
Domain description: Endonuclease/Exonuclease/phosphatase family 2
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

InterPro InterPro annotations
IPR036691
Domain description: Endonuclease/exonuclease/phosphatase superfamily
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
IPR005135
Domain description: Endonuclease/exonuclease/phosphatase
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
IPR000300
Domain description: Inositol polyphosphate-related phosphatase
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Quick links