5sdt

X-ray diffraction
1.94Å resolution

Structure of liver pyruvate kinase in complex with anthraquinone derivative 15

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151770 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyruvate kinase PKLR Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 447 amino acids
Theoretical weight: 48.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30613 (Residues: 34-160, 262-574; Coverage: 77%)
  • Best match: P30613-2 (Residues: 1-129, 231-543)
Gene names: PK1, PKL, PKLR
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 207.459Å b: 112.335Å c: 188.148Å
α: 90° β: 91.71° γ: 90°
R-values:
R R work R free
0.198 0.197 0.223
Expression system: Escherichia coli BL21(DE3)