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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c1(c(C)nc(c(n1)CCc2nc(cn2C)c3ccccc3)C)C, micromolar IC50=0.081773

Source organism: Homo sapiens
Biochemical function: phosphoric diester hydrolase activity
Biological process: signal transduction
Cellular component: not assigned

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EC 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase

Reaction catalysed:
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate
Systematic name:
3',5'-cyclic-nucleotide 5'-nucleotidohydrolase
Alternative Name(s):
  • 3', 5'-cyclic nucleoside monophosphate phosphodiesterase
  • 3',5'-cyclonucleotide phosphodiesterase
  • 3',5'-nucleotide phosphodiesterase
  • 3': 5'-monophosphate phosphodiesterase (cyclic CMP)
  • 3':5'-cyclic nucleotide 5'-nucleotidohydrolase
  • Cyclic 3',5'-mononucleotide phosphodiesterase
  • Cyclic 3',5'-nucleotide phosphodiesterase
  • Cyclic 3',5'-phosphodiesterase
  • Cyclic 3',5-nucleotide monophosphate phosphodiesterase
  • Cyclic AMP phosphodiesterase
  • Cyclic nucleotide phosphodiesterase
  • Cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP)
  • Nucleoside 3',5'-cyclic phosphate diesterase
  • Nucleoside-3',5-monophosphate phosphodiesterase
  • PDE

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR023088
Domain description: 3'5'-cyclic nucleotide phosphodiesterase
Occurring in:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
IPR003607
Domain description: HD/PDEase domain
Occurring in:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
IPR002073
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Occurring in:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
IPR023174
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, conserved site
Occurring in:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
IPR036971
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
Occurring in:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

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