› 5ssz

X-ray diffraction
1.02Å resolution

Crystal Structure of wild-type human formylglycine generating enzyme bound to Cu(I)

Released:
DOI: 10.2210/pdb5ssz/pdb
PDB entry 5ssz coloured by chain, front view.
PDB entry 5ssz coloured by chain, side view.
PDB entry 5ssz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Radhakrishnan K, Schlotawa L, Rudolph MG

Function and Biology Details

Reaction catalysed: 
A [sulfatase]-L-cysteine + O(2) + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H(2)O
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185466 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Formylglycine-generating enzyme Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 36.13 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8NBK3 (Residues: 73-374; Coverage: 89%)
Gene names: PSEC0152, SUMF1, UNQ3037/PRO9852
Sequence domains: Sulfatase-modifying factor enzyme 1

Ligands and Environments

3 bound ligands:
Ligand CU1 1 x CU1
Ligand NAG 1 x NAG
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Unit cell:
a: 43.513Å b: 62.024Å c: 110.021Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.131 0.131 0.142
Expression system: Trichoplusia ni

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