› 5sus

X-ray diffraction
2.35Å resolution

X-ray crystallographic structure of a covalent trimer derived from A-beta 17_36. X-ray diffractometer data set. (ORN)CVF(MEA)CED(ORN)AIIGL(ORN)V.

Released:
DOI: 10.2210/pdb5sus/pdb
PDB entry 5sus coloured by chain, front view.
PDB entry 5sus coloured by chain, side view.
PDB entry 5sus coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ.
Kreutzer AG, Yoo S, Spencer RK, Nowick JS
J Am Chem Soc 139 966-975 (2017)
PMID: 28001392

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo hexamer (preferred)
homo 24-mer
Assembly name:
PDBe Complex ID:
PDB-CPX-166080 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
16mer A-beta peptide: ORN-CYS-VAL-PHE-MEA-CYS-GLU-ASP-ORN-ALA-ILE-ILE-GLY-LEU-ORN-VAL Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 16 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand NA 1 x NA
2 modified residues:
Ligand ORN 12 x ORN
Ligand MEA 4 x MEA

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P6322
Unit cell:
a: 57.085Å b: 57.085Å c: 93.682Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.225 0.219 0.279
Expression system: Not provided

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Citations

7 review citations

Peptide-Based Vaccines: Current Progress and Future Challenges.
Malonis et al. (2020)
6 more