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Crystal structure of H6 hemagglutinin G225D mutant from Taiwan (2013) H6N1 influenza virus in complex with 3'-SLN

X-ray diffraction
2.864Å resolution
PDB entry 5t0d coloured by chain, front view.
PDB entry 5t0d coloured by chain, side view.
PDB entry 5t0d coloured by chain, top view.
Source organism: H6N1 subtype
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hemagglutinin HA2 chain and Hemagglutinin
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Multimeric state: hetero hexamer
Accessible surface area: 60465.7 Å2
Buried surface area: 30872.61 Å2
Dissociation area: 14,568.65 Å2
Dissociation energy (ΔGdiss): 167.28 kcal/mol
Dissociation entropy (TΔSdiss): 72.65 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-102268

Macromolecules

Hemagglutinin
Chains: A, C, E
Length: 333 amino acids
Theoretical weight: 37.39 KDa
Source organism: H6N1 subtype
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A0J9X268 (Residues: 1-333; Coverage: 100%)
Gene name: HA
Pfam: Haemagglutinin
InterPro:
CATH:
Hemagglutinin in PDB entry 5t0d, assembly 1, front view.
Hemagglutinin in PDB entry 5t0d, assembly 1, side view.
Hemagglutinin in PDB entry 5t0d, assembly 1, top view.
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Hemagglutinin HA2 chain
Chains: B, D, F
Length: 180 amino acids
Theoretical weight: 20.63 KDa
Source organism: H6N1 subtype
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A0J9X267 (Residues: 1-180; Coverage: 100%)
Gene name: HA
Pfam: Haemagglutinin
InterPro:
CATH: Hemagglutinin Ectodomain; Chain B
Hemagglutinin HA2 chain in PDB entry 5t0d, assembly 1, front view.
Hemagglutinin HA2 chain in PDB entry 5t0d, assembly 1, side view.
Hemagglutinin HA2 chain in PDB entry 5t0d, assembly 1, top view.
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