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The PROTAC MZ1 in complex with the second bromodomain of Brd4 and pVHL:ElonginC:ElonginB

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: ubiquitin-dependent protein catabolic process
Cellular component: elongin complex

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF17211
Domain description: VHL box domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
The deposited structure of PDB entry 5t35 contains 2 copies of Pfam domain PF17211 (VHL box domain) in von Hippel-Lindau disease tumor suppressor. Showing 1 copy in chain D.

PF01847
Domain description: VHL beta domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
The deposited structure of PDB entry 5t35 contains 2 copies of Pfam domain PF01847 (VHL beta domain) in von Hippel-Lindau disease tumor suppressor. Showing 1 copy in chain D.

PF03931
Domain description: Skp1 family, tetramerisation domain
Occurring in:
  1. Elongin-C
The deposited structure of PDB entry 5t35 contains 2 copies of Pfam domain PF03931 (Skp1 family, tetramerisation domain) in Elongin-C. Showing 1 copy in chain G.

PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Elongin-B
The deposited structure of PDB entry 5t35 contains 2 copies of Pfam domain PF00240 (Ubiquitin family) in Elongin-B. Showing 1 copy in chain B.

PF00439
Domain description: Bromodomain
Occurring in:
  1. Bromodomain-containing protein 4
The deposited structure of PDB entry 5t35 contains 2 copies of Pfam domain PF00439 (Bromodomain) in Bromodomain-containing protein 4. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001487
Domain description: Bromodomain
Occurring in:
  1. Bromodomain-containing protein 4
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Elongin-B
IPR011333
Domain description: SKP1/BTB/POZ domain superfamily
Occurring in:
  1. Elongin-C
IPR036427
Domain description: Bromodomain-like superfamily
Occurring in:
  1. Bromodomain-containing protein 4
IPR024048
Domain description: von Hippel-Lindau disease tumour suppressor, alpha domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR037139
Domain description: von Hippel-Lindau disease tumour suppressor, alpha domain superfamily
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR022772
Domain description: von Hippel-Lindau disease tumour suppressor, beta/alpha domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR037140
Domain description: von Hippel-Lindau disease tumour suppressor, beta domain superfamily
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR024053
Domain description: von Hippel-Lindau disease tumour suppressor, beta domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR036208
Domain description: VHL superfamily
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR016073
Domain description: SKP1 component, POZ domain
Occurring in:
  1. Elongin-C
IPR039948
Domain description: Elongin-C
Occurring in:
  1. Elongin-C
IPR001232
Domain description: S-phase kinase-associated protein 1-like
Occurring in:
  1. Elongin-C
IPR039049
Domain description: Elongin B
Occurring in:
  1. Elongin-B
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Elongin-B
IPR043509
Domain description: Brdt, bromodomain, repeat II
Occurring in:
  1. Bromodomain-containing protein 4

Structure domains

CATH CATH domains
1.10.750.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Elongin C; Chain C, domain 1
Homology: von Hippel-Lindau disease tumour suppressor, alpha domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
The deposited structure of PDB entry 5t35 contains 2 copies of CATH domain 1.10.750.10 (Elongin C; Chain C, domain 1) in von Hippel-Lindau disease tumor suppressor. Showing 1 copy in chain D.
2.60.40.780
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: von Hippel-Lindau disease tumour suppressor, beta domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
The deposited structure of PDB entry 5t35 contains 2 copies of CATH domain 2.60.40.780 (Immunoglobulin-like) in von Hippel-Lindau disease tumor suppressor. Showing 1 copy in chain D.
3.30.710.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Potassium Channel Kv1.1; Chain A
Homology: Potassium Channel Kv1.1; Chain A
Occurring in:
  1. Elongin-C
The deposited structure of PDB entry 5t35 contains 2 copies of CATH domain 3.30.710.10 (Potassium Channel Kv1.1; Chain A) in Elongin-C. Showing 1 copy in chain G.
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Elongin-B
The deposited structure of PDB entry 5t35 contains 2 copies of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Elongin-B. Showing 1 copy in chain B.
1.20.920.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Histone Acetyltransferase; Chain A
Homology: Bromodomain-like
Occurring in:
  1. Bromodomain-containing protein 4
The deposited structure of PDB entry 5t35 contains 2 copies of CATH domain 1.20.920.10 (Histone Acetyltransferase; Chain A) in Bromodomain-containing protein 4. Showing 1 copy in chain A.

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