EC 2.3.3.8: ATP citrate synthase
Reaction catalysed:
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA
Systematic name:
Acetyl-CoA:oxaloacetate C-acetyltransferase ((pro-S)-carboxymethyl-forming, ADP-phosphorylating)
Alternative Name(s):
- ATP citrate (pro-S)-lyase
- ATP-citrate (pro-S-)-lyase
- ATP-citric lyase
- ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP-dephosphorylating)
- Acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)
- Adenosine triphosphate citrate lyase
- Citrate cleavage enzyme
- Citrate-ATP lyase
- Citric cleavage enzyme
GO terms
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
InterPro annotations
IPR005811
Domain description:
ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain
Occurring in:
Occurring in:
Structure domains
CATH domains
3.40.50.261
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
Succinyl-CoA synthetase domains
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>5tdm</span> contains 1 copy of CATH domain <span class='highlight'>3.40.50.261 (Rossmann fold)</span> in <span class='highlight'>ATP-citrate synthase</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 5tdm contains 1 copy of CATH domain 3.40.50.261 (Rossmann fold) in ATP-citrate synthase. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/5tdm_1_A_CATH_3.40.50.261_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>5tdm</span> contains 1 copy of CATH domain <span class='highlight'>3.40.50.261 (Rossmann fold)</span> in <span class='highlight'>ATP-citrate synthase</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 5tdm contains 1 copy of CATH domain 3.40.50.261 (Rossmann fold) in ATP-citrate synthase. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/5tdm_2_B_CATH_3.40.50.261_image-200x200.png)
3.30.470.20
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
D-amino Acid Aminotransferase; Chain A, domain 1
Homology:
ATP-grasp fold, B domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>5tdm</span> contains 1 copy of CATH domain <span class='highlight'>3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1)</span> in <span class='highlight'>ATP-citrate synthase</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 5tdm contains 1 copy of CATH domain 3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1) in ATP-citrate synthase. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/5tdm_1_A_CATH_3.30.470.20_image-200x200.png)
3.40.50.720
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
NAD(P)-binding Rossmann-like Domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>5tdm</span> contains 1 copy of CATH domain <span class='highlight'>3.40.50.720 (Rossmann fold)</span> in <span class='highlight'>ATP-citrate synthase</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 5tdm contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in ATP-citrate synthase. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/5tdm_2_B_CATH_3.40.50.720_image-200x200.png)