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Crystal Structure of Fumarylacetoacetate hydrolase from Burkholderia xenovorans LB400

Source organism: Paraburkholderia xenovorans LB400
Biochemical function: metal ion binding
Biological process: homogentisate catabolic process
Cellular component: not assigned

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EC 3.7.1.2: Fumarylacetoacetase

Reaction catalysed:
4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate
Systematic name:
4-fumarylacetoacetate fumarylhydrolase
Alternative Name(s):
  • Beta-diketonase
  • Fumarylacetoacetate hydrolase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01557
Domain description: Fumarylacetoacetate (FAA) hydrolase family
Occurring in:
  1. fumarylacetoacetase
The deposited structure of PDB entry 5ti1 contains 8 copies of Pfam domain PF01557 (Fumarylacetoacetate (FAA) hydrolase family) in fumarylacetoacetase. Showing 1 copy in chain H.

PF09298
Domain description: Fumarylacetoacetase N-terminal
Occurring in:
  1. fumarylacetoacetase
The deposited structure of PDB entry 5ti1 contains 8 copies of Pfam domain PF09298 (Fumarylacetoacetase N-terminal) in fumarylacetoacetase. Showing 1 copy in chain H.

InterPro InterPro annotations
IPR036663
Domain description: Fumarylacetoacetase-like, C-terminal domain superfamily
Occurring in:
  1. fumarylacetoacetase
IPR005959
Domain description: Fumarylacetoacetase
Occurring in:
  1. fumarylacetoacetase
IPR036462
Domain description: Fumarylacetoacetase, N-terminal domain superfamily
Occurring in:
  1. fumarylacetoacetase
IPR011234
Domain description: Fumarylacetoacetase-like, C-terminal
Occurring in:
  1. fumarylacetoacetase
IPR015377
Domain description: Fumarylacetoacetase, N-terminal
Occurring in:
  1. fumarylacetoacetase

Structure domains

CATH CATH domains
3.90.850.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Fumarylacetoacetate hydrolase; domain 2
Homology: Fumarylacetoacetase-like, C-terminal domain
Occurring in:
  1. fumarylacetoacetase
The deposited structure of PDB entry 5ti1 contains 8 copies of CATH domain 3.90.850.10 (Fumarylacetoacetate hydrolase; domain 2) in fumarylacetoacetase. Showing 1 copy in chain H.
2.30.30.230
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: Fumarylacetoacetase, N-terminal domain
Occurring in:
  1. fumarylacetoacetase
The deposited structure of PDB entry 5ti1 contains 8 copies of CATH domain 2.30.30.230 (SH3 type barrels.) in fumarylacetoacetase. Showing 1 copy in chain H.

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