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Human Gasdermin-B and disease: Sulfatide Binding, Caspase cleavage, and Structural impact of Asthma- and IBS-Associated Polymorphism

Chao LK, Kulakova L, Herzberg O
Proc. Natl. Acad. Sci. U.S.A. (2017)
Cited: 86 times

Articles - 5tib mentioned but not cited (5)

  1. Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein. Chao KL, Kulakova L, Herzberg O. Proc Natl Acad Sci U S A 114 E1128-E1137 (2017)
  2. Conservation of binding properties in protein models. Egbert M, Porter KA, Ghani U, Kotelnikov S, Nguyen T, Ashizawa R, Kozakov D, Vajda S. Comput Struct Biotechnol J 19 2549-2566 (2021)
  3. Compressive Behavior of Al-TiB2 Composite Foams Fabricated under Increased Pressure. Yu Y, Cao Z, Wang J, Tu G, Mu Y. Materials (Basel) 14 5112 (2021)
  4. Influences of Increased Pressure Foaming on the Cellular Structure and Compressive Properties of In Situ Al-4.5%Cu-xTiB2 Composite Foams with Different Particle Fraction. Niu Z, An Z, Jiang Z, Cao Z, Yu Y. Materials (Basel) 14 2612 (2021)
  5. Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016). Kryshtafovych A, Albrecht R, Baslé A, Bule P, Caputo AT, Carvalho AL, Chao KL, Diskin R, Fidelis K, Fontes CMGA, Fredslund F, Gilbert HJ, Goulding CW, Hartmann MD, Hayes CS, Herzberg O, Hill JC, Joachimiak A, Kohring GW, Koning RI, Lo Leggio L, Mangiagalli M, Michalska K, Moult J, Najmudin S, Nardini M, Nardone V, Ndeh D, Nguyen TH, Pintacuda G, Postel S, van Raaij MJ, Roversi P, Shimon A, Singh AK, Sundberg EJ, Tars K, Zitzmann N, Schwede T. Proteins 86 Suppl 1 27-50 (2018)


Reviews citing this publication (46)

  1. Gasdermins: Effectors of Pyroptosis. Kovacs SB, Miao EA. Trends Cell Biol. 27 673-684 (2017)
  2. Channelling inflammation: gasdermins in physiology and disease. Liu X, Xia S, Zhang Z, Wu H, Lieberman J. Nat Rev Drug Discov 20 384-405 (2021)
  3. The gasdermins, a protein family executing cell death and inflammation. Broz P, Pelegrín P, Shao F. Nat Rev Immunol 20 143-157 (2020)
  4. Mechanism and Regulation of Gasdermin-Mediated Cell Death. Xia S, Hollingsworth LR, Wu H. Cold Spring Harb Perspect Biol 12 a036400 (2020)
  5. Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis. de Vasconcelos NM, Lamkanfi M. Cold Spring Harb Perspect Biol 12 a036392 (2020)
  6. NLRP3 inflammasome activation and cell death. Huang Y, Xu W, Zhou R. Cell Mol Immunol 18 2114-2127 (2021)
  7. Pyroptosis in inflammatory diseases and cancer. Rao Z, Zhu Y, Yang P, Chen Z, Xia Y, Qiao C, Liu W, Deng H, Li J, Ning P, Wang Z. Theranostics 12 4310-4329 (2022)
  8. Pore-forming proteins as drivers of membrane permeabilization in cell death pathways. Vandenabeele P, Bultynck G, Savvides SN. Nat Rev Mol Cell Biol 24 312-333 (2023)
  9. Gasdermin D in pyroptosis. Burdette BE, Esparza AN, Zhu H, Wang S. Acta Pharm Sin B 11 2768-2782 (2021)
  10. Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity. Hou J, Hsu JM, Hung MC. Mol Cell 81 4579-4590 (2021)
  11. Pyroptosis, metabolism, and tumor immune microenvironment. Du T, Gao J, Li P, Wang Y, Qi Q, Liu X, Li J, Wang C, Du L. Clin Transl Med 11 e492 (2021)
  12. Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease. Yuan YY, Xie KX, Wang SL, Yuan LW. Gastroenterol Rep (Oxf) 6 167-176 (2018)
  13. Role of pyroptosis in inflammation and cancer. Wei X, Xie F, Zhou X, Wu Y, Yan H, Liu T, Huang J, Wang F, Zhou F, Zhang L. Cell Mol Immunol 19 971-992 (2022)
  14. Pyroptosis, a New Breakthrough in Cancer Treatment. Wu D, Wei C, Li Y, Yang X, Zhou S. Front Oncol 11 698811 (2021)
  15. Chemical Modulation of Gasdermin-Mediated Pyroptosis and Therapeutic Potential. Ryder CB, Kondolf HC, O'Keefe ME, Zhou B, Abbott DW. J Mol Biol 434 167183 (2022)
  16. The Versatile Gasdermin Family: Their Function and Roles in Diseases. Zou J, Zheng Y, Huang Y, Tang D, Kang R, Chen R. Front Immunol 12 751533 (2021)
  17. Biological Functions of Gasdermins in Cancer: From Molecular Mechanisms to Therapeutic Potential. Wang M, Chen X, Zhang Y. Front Cell Dev Biol 9 638710 (2021)
  18. Mechanistic Insights into Gasdermin Pore Formation and Regulation in Pyroptosis. Wang C, Ruan J. J Mol Biol 434 167297 (2022)
  19. New Insights Relating Gasdermin B to the Onset of Childhood Asthma. Schoettler N, Dissanayake E, Craven MW, Yee JS, Eliason J, Schauberger EM, Lemanske RF, Ober C, Gern JE. Am J Respir Cell Mol Biol 67 430-437 (2022)
  20. Pyroptosis in development, inflammation and disease. Pan Y, Cai W, Huang J, Cheng A, Wang M, Yin Z, Jia R. Front Immunol 13 991044 (2022)
  21. Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections. Zhang G, Wang J, Zhao Z, Xin T, Fan X, Shen Q, Raheem A, Lee CR, Jiang H, Ding J. Cell Death Dis 13 637 (2022)
  22. Gasdermin Family: a Promising Therapeutic Target for Stroke. Chen S, Mei S, Luo Y, Wu H, Zhang J, Zhu J. Transl Stroke Res 9 555-563 (2018)
  23. Gasdermins and pyroptosis in the kidney. Elias EE, Lyons B, Muruve DA. Nat Rev Nephrol 19 337-350 (2023)
  24. No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death. Weir A, Vince JE. Biochem J 479 1083-1102 (2022)
  25. Novel Insights Into the Interactions Between the Gut Microbiome, Inflammasomes, and Gasdermins During Colorectal Cancer. Privitera G, Rana N, Scaldaferri F, Armuzzi A, Pizarro TT. Front Cell Infect Microbiol 11 806680 (2021)
  26. Pyroptosis Provides New Strategies for the Treatment of Cancer. Jia Y, Wang X, Deng Y, Li S, Xu X, Qin Y, Peng L. J Cancer 14 140-151 (2023)
  27. Role of GSDMB in Pyroptosis and Cancer. Li L, Li Y, Bai Y. Cancer Manag Res 12 3033-3043 (2020)
  28. Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs. Zhang S, Liang Y, Yao J, Li DF, Wang LS. Front Pharmacol 13 833588 (2022)
  29. The enigmatic roles of epithelial gasdermin B: Recent discoveries and controversies. Ivanov AI, Rana N, Privitera G, Pizarro TT. Trends Cell Biol 33 48-59 (2023)
  30. GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy. Zuo Y, Chen L, Gu H, He X, Ye Z, Wang Z, Shao Q, Xue C. Expert Rev Mol Med 23 e23 (2021)
  31. Gasdermin D kills bacteria. Salami A, Bettadapura S, Wang S. Microbiol Res 272 127383 (2023)
  32. Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases. Wu D, Chen Y, Sun Y, Gao Q, Yu B, Jiang X, Guo M. J Cell Commun Signal 14 293-301 (2020)
  33. Gasdermins assemble; recent developments in bacteriology and pharmacology. Greenwood CS, Wynosky-Dolfi MA, Beal AM, Booty LM. Front Immunol 14 1173519 (2023)
  34. Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites. Wang S, Moreau F, Chadee K. Front Immunol 13 900553 (2022)
  35. How Pyroptosis Contributes to Inflammation and Fibroblast-Macrophage Cross-Talk in Rheumatoid Arthritis. Demarco B, Danielli S, Fischer FA, Bezbradica JS. Cells 11 1307 (2022)
  36. Mechanisms of Gasdermin Recognition by Proteases. Liu Z, Busscher BM, Storl-Desmond M, Xiao TS. J Mol Biol 434 167274 (2022)
  37. Microglial pyroptosis: Therapeutic target in secondary brain injury following intracerebral hemorrhage. Gu L, Sun M, Li R, Tao Y, Luo X, Zhang X, Yuan Y, Xie Z. Front Cell Neurosci 16 971469 (2022)
  38. Pyroptosis and pyroptosis-inducing cancer drugs. Yang F, Bettadapura SN, Smeltzer MS, Zhu H, Wang S. Acta Pharmacol Sin (2022)
  39. Pyroptosis and respiratory diseases: A review of current knowledge. Sun J, Li Y. Front Immunol 13 920464 (2022)
  40. Pyroptosis in Liver Disease: New Insights into Disease Mechanisms. Wu J, Lin S, Wan B, Velani B, Zhu Y. Aging Dis 10 1094-1108 (2019)
  41. Pyroptosis in spinal cord injury. Yin J, Gong G, Wan W, Liu X. Front Cell Neurosci 16 949939 (2022)
  42. Role of inflammasome in severe, steroid-resistant asthma. Khalil BA, Sharif-Askari NS, Halwani R. Curr Res Immunol 4 100061 (2023)
  43. Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity. Tsuchiya K. Int J Mol Sci 22 (2021)
  44. The gasdermin protein family: emerging roles in gastrointestinal health and disease. Privitera G, Rana N, Armuzzi A, Pizarro TT. Nat Rev Gastroenterol Hepatol 20 366-387 (2023)
  45. The role of pyroptosis and its crosstalk with immune therapy in breast cancer. Wu L, Lu H, Pan Y, Liu C, Wang J, Chen B, Wang Y. Front Immunol 13 973935 (2022)
  46. The role of pyroptosis in inflammatory diseases. Chai R, Li Y, Shui L, Ni L, Zhang A. Front Cell Dev Biol 11 1173235 (2023)

Articles citing this publication (35)

  1. Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions. Hansen JM, de Jong MF, Wu Q, Zhang LS, Heisler DB, Alto LT, Alto NM. Cell 184 3178-3191.e18 (2021)
  2. Letter Autoimmune disease variants regulate GSDMB gene expression in human immune cells and whole blood. Hu Y, Jin S, Cheng L, Liu G, Jiang Q. Proc. Natl. Acad. Sci. U.S.A. 114 E7860-E7862 (2017)
  3. Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization. Liu Z, Wang C, Yang J, Zhou B, Yang R, Ramachandran R, Abbott DW, Xiao TS. Immunity 51 43-49.e4 (2019)
  4. Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C. Zhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z, Ruan HB. Immunity 55 623-638.e5 (2022)
  5. Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis. Song M, Wang J, Sun Y, Pang J, Li X, Liu Y, Zhou Y, Yang P, Fan T, Liu Y, Li Z, Qi X, Li B, Zhang X, Wang J, Wang C. Acta Pharm Sin B 12 1213-1224 (2022)
  6. Pyroptosis-Related Signature Predicts Prognosis and Immunotherapy Efficacy in Muscle-Invasive Bladder Cancer. Zhang Q, Tan Y, Zhang J, Shi Y, Qi J, Zou D, Ci W. Front Immunol 13 782982 (2022)
  7. GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis. Rana N, Privitera G, Kondolf HC, Bulek K, Lechuga S, De Salvo C, Corridoni D, Antanaviciute A, Maywald RL, Hurtado AM, Zhao J, Huang EH, Li X, Chan ER, Simmons A, Bamias G, Abbott DW, Heaney JD, Ivanov AI, Pizarro TT. Cell 185 283-298.e17 (2022)
  8. Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition. Liu Z, Wang C, Rathkey JK, Yang J, Dubyak GR, Abbott DW, Xiao TS. Structure 26 778-784.e3 (2018)
  9. A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis. Panganiban RA, Sun M, Dahlin A, Park HR, Kan M, Himes BE, Mitchel JA, Iribarren C, Jorgenson E, Randell SH, Israel E, Tantisira K, Shore S, Park JA, Weiss ST, Wu AC, Lu Q. J. Allergy Clin. Immunol. 142 1469-1478.e2 (2018)
  10. Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood. Hallmark B, Wegienka G, Havstad S, Billheimer D, Ownby D, Mendonca EA, Gress L, Stern DA, Myers JB, Khurana Hershey GK, Hoepner L, Miller RL, Lemanske RF, Jackson DJ, Gold DR, O'Connor GT, Nicolae DL, Gern JE, Ober C, Wright AL, Martinez FD. Am J Respir Crit Care Med 203 864-870 (2021)
  11. GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. Chen Q, Shi P, Wang Y, Zou D, Wu X, Wang D, Hu Q, Zou Y, Huang Z, Ren J, Lin Z, Gao X. J Mol Cell Biol 11 496-508 (2019)
  12. Cell Death in the Lung: The Apoptosis-Necroptosis Axis. Sauler M, Bazan IS, Lee PJ. Annu. Rev. Physiol. 81 375-402 (2019)
  13. Knocking 'em Dead: Pore-Forming Proteins in Immune Defense. Liu X, Lieberman J. Annu Rev Immunol 38 455-485 (2020)
  14. Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line. Toka FN, Dunaway K, Smaltz F, Szulc-Dąbrowska L, Drnevich J, Mielcarska MB, Bossowska-Nowicka M, Schweizer M. BMC Genomics 20 15 (2019)
  15. Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells. Oltra SS, Colomo S, Sin L, Pérez-López M, Lázaro S, Molina-Crespo A, Choi KH, Ros-Pardo D, Martínez L, Morales S, González-Paramos C, Orantes A, Soriano M, Hernández A, Lluch A, Rojo F, Albanell J, Gómez-Puertas P, Ko JK, Sarrió D, Moreno-Bueno G. Cell Death Differ 30 1366-1381 (2023)
  16. GSDMEa-mediated pyroptosis is bi-directionally regulated by caspase and required for effective bacterial clearance in teleost. Xu H, Jiang S, Yu C, Yuan Z, Sun L. Cell Death Dis 13 491 (2022)
  17. Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8. Yin H, Zheng J, He Q, Zhang X, Li X, Ma Y, Liang X, Gao J, Kocsis BL, Li Z, Liu X, Alto NM, Li L, Zhang H. Nat Commun 14 61 (2023)
  18. Protein engineering reveals that gasdermin A preferentially targets mitochondrial membranes over the plasma membrane during pyroptosis. Kondolf HC, D'Orlando DA, Dubyak GR, Abbott DW. J Biol Chem 299 102908 (2023)
  19. Risk of Prevalent Asthma among Children Affected by Inflammatory Bowel Disease: A Population-Based Birth Cohort Study. Barbiellini Amidei C, Zingone F, Zanier L, Canova C. Int J Environ Res Public Health 17 (2020)
  20. A comprehensive analysis of gasdermin family gene as therapeutic targets in pan-cancer. Huo CL, Deng Y, Sun ZG. Sci Rep 12 13329 (2022)
  21. African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans. Washington C, Dapas M, Biddanda A, Magnaye KM, Aneas I, Helling BA, Szczesny B, Boorgula MP, Taub MA, Kenny E, Mathias RA, Barnes KC, CAAPA, Khurana Hershey GK, Kercsmar CM, Gereige JD, Makhija M, Gruchalla RS, Gill MA, Liu AH, Rastogi D, Busse W, Gergen PJ, Visness CM, Gold DR, Hartert T, Johnson CC, Lemanske RF, Martinez FD, Miller RL, Ownby D, Seroogy CM, Wright AL, Zoratti EM, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Nobrega MA, Altman MC, Jackson DJ, Gern JE, McKennan CG, Ober C. Genome Med 14 112 (2022)
  22. Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis. Kong Q, Xia S, Pan X, Ye K, Li Z, Li H, Tang X, Sahni N, Yi SS, Liu X, Wu H, Elowitz MB, Lieberman J, Zhang Z. Sci Immunol 8 eadg3196 (2023)
  23. Systematic Review Association Between GSDMB Gene Polymorphism and Cervical Cancer in the Northeast Chinese Han Population. Li S, Li X, Zhang S, Feng Y, Jia T, Zhu M, Fang L, Gong L, Dong S, Kong X, Wang Z, Sun L. Front Genet 13 860727 (2022)
  24. Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level. Zhang D, Li Y, Du C, Sang L, Liu L, Li Y, Wang F, Fan W, Tang P, Zhang S, Chen D, Wang Y, Wang X, Xie X, Jiang Z, Song Y, Guo R. J Transl Med 20 363 (2022)
  25. GSDMB N-terminal assembles in plasma membrane to execute pyroptotic cell death. Gong W, Liu P, Liu J, Li Y, Zheng T, Wu X, Zhao Y, Ren J. Genes Dis 9 1405-1407 (2022)
  26. GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. López-Isac E, Acosta-Herrera M, Kerick M, Assassi S, Satpathy AT, Granja J, Mumbach MR, Beretta L, Simeón CP, Carreira P, Ortego-Centeno N, Castellvi I, Bossini-Castillo L, Carmona FD, Orozco G, Hunzelmann N, Distler JHW, Franke A, Lunardi C, Moroncini G, Gabrielli A, de Vries-Bouwstra J, Wijmenga C, Koeleman BPC, Nordin A, Padyukov L, Hoffmann-Vold AM, Lie B, European Scleroderma Group†, Proudman S, Stevens W, Nikpour M, Australian Scleroderma Interest Group (ASIG), Vyse T, Herrick AL, Worthington J, Denton CP, Allanore Y, Brown MA, Radstake TRDJ, Fonseca C, Chang HY, Mayes MD, Martin J. Nat Commun 10 4955 (2019)
  27. Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation. Gámez-Chiachio M, Molina-Crespo Á, Ramos-Nebot C, Martinez-Val J, Martinez L, Gassner K, Llobet FJ, Soriano M, Hernandez A, Cordani M, Bernadó-Morales C, Diaz E, Rojo-Sebastian A, Triviño JC, Sanchez L, Rodríguez-Barrueco R, Arribas J, Llobet-Navás D, Sarrió D, Moreno-Bueno G. J Exp Clin Cancer Res 41 285 (2022)
  28. Gasdermin-B Pro-Tumor Function in Novel Knock-in Mouse Models Depends on the in vivo Biological Context. Sarrio D, Rojo-Sebastián A, Teijo A, Pérez-López M, Díaz-Martín E, Martínez L, Morales S, García-Sanz P, Palacios J, Moreno-Bueno G. Front Cell Dev Biol 10 813929 (2022)
  29. Lipids that directly regulate innate immune signal transduction. Barnett KC, Kagan JC. Innate Immun 26 4-14 (2020)
  30. Editorial Live or let die: Translational insights and clinical perspectives of gasdermin B-dependent intestinal epithelial cell fate. Privitera G, Pizarro TT. Clin Transl Med 12 e787 (2022)
  31. Pyroptosis-related genes GSDMB, GSDMC, and AIM2 polymorphisms are associated with risk of non-small cell lung cancer in a Chinese Han population. Zhang X, Liu R. Front Genet 14 1212465 (2023)
  32. Editorial Regulating GSDMB pore formation: to ignite or inhibit? Ruan J. Cell Death Differ (2023)
  33. Letter Reply to HU et al.: On the interpretation of gasdermin-B expression quantitative trait loci data. Pal LR, Chao KL, Moult J, Herzberg O. Proc. Natl. Acad. Sci. U.S.A. 114 E7863-E7864 (2017)
  34. Structural basis for GSDMB pore formation and its targeting by IpaH7.8. Wang C, Shivcharan S, Tian T, Wright S, Ma D, Chang J, Li K, Song K, Xu C, Rathinam VA, Ruan J. Nature 616 590-597 (2023)
  35. Systematic pan-cancer analysis identifies gasdermin B as an immunological and prognostic biomarker for kidney renal clear cell carcinoma. Liu X, Xie F, Ding J, Li S, Li J. Front Oncol 13 1164214 (2023)


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