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Crystal Structure of Eukaryotic Hydrolase

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.2.1.169: Protein O-GlcNAcase

Reaction catalysed:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine
Systematic name:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolase
Alternative Name(s):
  • BtGH84
  • Glycoside hydrolase O-GlcNAcase
  • O-GlcNAc hydrolase
  • O-GlcNAcase
  • OGA

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF07555
Domain description: beta-N-acetylglucosaminidase
Occurring in:
  1. Protein O-GlcNAcase
The deposited structure of PDB entry 5tke contains 2 copies of Pfam domain PF07555 (beta-N-acetylglucosaminidase ) in Protein O-GlcNAcase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR011496
Domain description: Beta-N-acetylglucosaminidase, catalytic domain
Occurring in:
  1. Protein O-GlcNAcase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Protein O-GlcNAcase

Structure domain

CATH CATH domain
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Protein O-GlcNAcase
The deposited structure of PDB entry 5tke contains 2 copies of CATH domain 3.20.20.80 (TIM Barrel) in Protein O-GlcNAcase. Showing 1 copy in chain B.

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