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Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC compound, 6-(4-((1R,4S,6R)-6-((4-bromophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenoxy)hexanoic acid

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Estrogen receptor
The deposited structure of PDB entry 5tm6 contains 2 copies of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Estrogen receptor. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Estrogen receptor
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Estrogen receptor
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Estrogen receptor

Structure domain

CATH CATH domain
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Estrogen receptor
The deposited structure of PDB entry 5tm6 contains 2 copies of CATH domain 1.10.565.10 (Retinoid X Receptor) in Estrogen receptor. Showing 1 copy in chain B.

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