› 5tpk

X-ray diffraction
2Å resolution

Crystal Structure of Mouse Protocadherin-15 EC7-8 V875A

Released:
DOI: 10.2210/pdb5tpk/pdb
PDB entry 5tpk coloured by chain, front view.
PDB entry 5tpk coloured by chain, side view.
PDB entry 5tpk coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
Choudhary D, Narui Y, Neel BL, Wimalasena LN, Klanseck CF, De-la-Torre P, Chen C, Araya-Secchi R, Tamilselvan E, Sotomayor M
OpenAccess logo Proc Natl Acad Sci U S A 117 24837-24848 (2020)
PMID: 32963095

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-573178 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protocadherin-15 Chain: A
Molecule details ›
Chain: A
Length: 218 amino acids
Theoretical weight: 24.24 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99PJ1 (Residues: 715-923; Coverage: 11%)
Gene name: Pcdh15
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 135.796Å b: 22.99Å c: 70.741Å
α: 90° β: 97.27° γ: 90°
R-values:
R R work R free
0.192 0.19 0.229
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Mechanotransduction in mammalian sensory hair cells.
Caprara et al. (2022)
3 more