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CryoEM reconstruction of human IKK1, open conformation 1

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

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EC 2.7.11.10: I-kappa-B kinase

Reaction catalysed:
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]
Systematic name:
ATP:[I-kappa-B protein] phosphotransferase
Alternative Name(s):
  • CHUK
  • IKBKA
  • IKBKB
  • IKK
  • IKK-1
  • IKK-2
  • Inhibitor of NF-kappa-B kinase
  • Inhibitor of NF-kappa-B kinase
  • STK12
  • TANK-binding kinase 1
  • TBK1

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF18397
Domain description: IQBAL scaffold dimerization domain
Occurring in:
  1. Inhibitor of nuclear factor kappa-B kinase subunit alpha
The deposited structure of PDB entry 5tqw contains 2 copies of Pfam domain PF18397 (IQBAL scaffold dimerization domain) in Inhibitor of nuclear factor kappa-B kinase subunit alpha. Showing 1 copy in chain A.

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Inhibitor of nuclear factor kappa-B kinase subunit alpha
The deposited structure of PDB entry 5tqw contains 2 copies of Pfam domain PF00069 (Protein kinase domain) in Inhibitor of nuclear factor kappa-B kinase subunit alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Inhibitor of nuclear factor kappa-B kinase subunit alpha
IPR046375
Domain description: IKBKB, scaffold dimerization domain superfamily
Occurring in:
  1. Inhibitor of nuclear factor kappa-B kinase subunit alpha
IPR041185
Domain description: IKBKB, scaffold dimerization domain
Occurring in:
  1. Inhibitor of nuclear factor kappa-B kinase subunit alpha
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Inhibitor of nuclear factor kappa-B kinase subunit alpha
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Inhibitor of nuclear factor kappa-B kinase subunit alpha
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Inhibitor of nuclear factor kappa-B kinase subunit alpha

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