› 5tzl

X-ray diffraction
1.4Å resolution

Structure of transthyretin in complex with the kinetic stabilizer 201

Released:
DOI: 10.2210/pdb5tzl/pdb
PDB entry 5tzl coloured by chain, front view.
PDB entry 5tzl coloured by chain, side view.
PDB entry 5tzl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.
Connelly S, Mortenson DE, Choi S, Wilson IA, Powers ET, Kelly JW, Johnson SM
Bioorg Med Chem Lett 27 3441-3449 (2017)
PMID: 28625364

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

1 bound ligand:
Ligand IIH 2 x IIH
1 modified residue:
Ligand OCS 2 x OCS

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P21212
Unit cell:
a: 43.265Å b: 85.467Å c: 64.285Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.134 0.133 0.167
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors.
Guo et al. (2020)
4 other articles

4 mentions without citation

Update on the clinical utility of an RNA interference-based treatment: focus on Patisiran.
Rizk et al. (2017)
3 more