› 5u6r

Electron Microscopy
5.7Å resolution

E. coli CTP synthase CC mutant filament (product-bound)

Released:
DOI: 10.2210/pdb5u6r/pdb
PDB entry 5u6r coloured by chain, front view.
PDB entry 5u6r coloured by chain, side view.
PDB entry 5u6r coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Human CTP synthase filament structure reveals the active enzyme conformation.
Lynch EM, Hicks DR, Shepherd M, Endrizzi JA, Maker A, Hansen JM, Barry RM, Gitai Z, Baldwin EP, Kollman JM
OpenAccess logo Nat Struct Mol Biol 24 507-514 (2017)
PMID: 28459447
Related structures: EMD-8513

Function and Biology Details

Reaction catalysed: 
(1a) L-glutamine + H(2)O = L-glutamate + NH(3)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 28-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141590 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CTP synthase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 545 amino acids
Theoretical weight: 60.45 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A7E5 (Residues: 1-545; Coverage: 100%)
Gene names: JW2751, b2780, pyrG
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CTP 4 x CTP
Ligand ADP 4 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.7Å
Relevant EMDB volumes: EMD-8513
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Enzymatic Noncovalent Synthesis.
He et al. (2020)
15 more

1 mention without citation

Human CTP synthase filament structure reveals the active enzyme conformation.
Lynch et al. (2017)