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A circularly permuted version of PvdQ (cpPvdQ)

Source organism: Pseudomonas aeruginosa
Biochemical function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Biological process: antibiotic biosynthetic process
Cellular component: not assigned

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EC 3.5.1.97: Acyl-homoserine-lactone acylase

Reaction catalysed:
An N-acyl-L-homoserine lactone + H(2)O = L-homoserine lactone + a carboxylate
Systematic name:
N-acyl-L-homoserine-lactone amidohydrolase
Alternative Name(s):
  • AHL-acylase
  • Acyl-homoserine lactone acylase
  • AiiD
  • N-acyl-homoserine lactone acylase
  • PA2385 protein
  • PvdQ
  • QuiP
  • Quorum-quenching AHL acylase
  • Quorum-quenching enzyme

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01804
Domain description: Penicillin amidase
Occurring in:
  1. Acyl-homoserine lactone acylase PvdQ subunit beta
The deposited structure of PDB entry 5ubl contains 1 copy of Pfam domain PF01804 (Penicillin amidase) in Acyl-homoserine lactone acylase PvdQ subunit beta. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. Acyl-homoserine lactone acylase PvdQ subunit beta
IPR002692
Domain description: Penicillin/GL-7-ACA/AHL/aculeacin-A acylase
Occurring in:
  1. Acyl-homoserine lactone acylase PvdQ subunit beta
IPR023343
Domain description: Penicillin amidase type, domain 1
Occurring in:
  1. Acyl-homoserine lactone acylase PvdQ subunit beta
IPR043147
Domain description: Penicillin amidase type, A-knob
Occurring in:
  1. Acyl-homoserine lactone acylase PvdQ subunit beta
IPR043146
Domain description: Penicillin amidase type, N-terminal domain, B-knob
Occurring in:
  1. Acyl-homoserine lactone acylase PvdQ subunit beta

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