› 5uga

X-ray diffraction
1.82Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132671 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 329 amino acids
Theoretical weight: 37.58 KDa
Source organism: Homo sapiens
Expression system: Spodoptera aff. frugiperda 2 RZ-2014
UniProt:
  • Canonical: P00533 (Residues: 695-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand 8BM 1 x 8BM
Ligand SO4 2 x SO4
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 40.904Å b: 69.595Å c: 110.218Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.233 0.264
Expression system: Spodoptera aff. frugiperda 2 RZ-2014

Quick links

Citations

9 review citations

Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer.
Wu et al. (2018)
8 more

1 mention without citation

Identification of Druggable Kinase Target Conformations Using Markov Model Metastable States Analysis of apo-Abl.
Paul et al. (2020)