› 5ugk

Solid-state NMR

Zinc-Binding Structure of a Catalytic Amyloid from Solid-State NMR Spectroscopy

Released:
DOI: 10.2210/pdb5ugk/pdb
PDB entry 5ugk coloured by chain, ensemble of 20 models, front view.
PDB entry 5ugk coloured by chain, ensemble of 20 models, side view.
PDB entry 5ugk coloured by chain, ensemble of 20 models, top view.
Source organism: synthetic construct
Primary publication:
Zinc-binding structure of a catalytic amyloid from solid-state NMR.
Lee M, Wang T, Makhlynets OV, Wu Y, Polizzi NF, Wu H, Gosavi PM, Stöhr J, Korendovych IV, DeGrado WF, Hong M
Proc Natl Acad Sci U S A 114 6191-6196 (2017)
PMID: 28566494

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166161 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ILE-HIS-VAL-HIS-LEU-GLN-ILE Chains: A, C, E, G, I, K, O, Q, S, U, W, Y
Molecule details ›
Chains: A, C, E, G, I, K, O, Q, S, U, W, Y
Length: 7 amino acids
Theoretical weight: 861 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 12 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 3%
Refinement method: torsion angle dynamics
Expression system: Not provided

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Citations

10 review citations

A new era for understanding amyloid structures and disease.
Iadanza et al. (2018)
9 more

6 mentions without citation

De novo protein design, a retrospective.
Korendovych et al. (2020)
5 more