› 5un0

X-ray diffraction
3Å resolution

Crystal Structure of Mycobacterium Tuberculosis Proteasome-assembly chaperone homologue Rv2125

Released:
DOI: 10.2210/pdb5un0/pdb
PDB entry 5un0 coloured by chain, front view.
PDB entry 5un0 coloured by chain, side view.
PDB entry 5un0 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2).
Bai L, Jastrab JB, Isasa M, Hu K, Yu H, Gygi SP, Darwin KH, Li H
J Bacteriol 199 (2017)
PMID: 28193903

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128475 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PAC2 family protein Chains: 1, 2, 3
Molecule details ›
Chains: 1, 2, 3
Length: 251 amino acids
Theoretical weight: 27.49 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: O33260 (Residues: 17-260; Coverage: 84%)
Gene name: Rv2125
Sequence domains: PAC2 family
Structure domains: PAC-like subunit

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25, NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 138.25Å b: 79.76Å c: 89.03Å
α: 90° β: 103.57° γ: 90°
R-values:
R R work R free
0.239 0.236 0.289
Expression system: Escherichia coli

Quick links

Citations

2 review citations

AAA+ Machines of Protein Destruction in Mycobacteria.
Alhuwaider et al. (2017)
1 more

1 mention without citation

Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2).
Bai et al. (2017)