Structure analysis

Enantiomer-Specific Binding of the Potent Antinociceptive Agent SBFI-26 to Anandamide transporters FABP5

X-ray diffraction
2.198Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 7457.62 Å2
Buried surface area: 1141.55 Å2
Dissociation area: 335.18 Å2
Dissociation energy (ΔGdiss): -7.27 kcal/mol
Dissociation entropy (TΔSdiss): 3.79 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169567
Assembly 2
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 7351.06 Å2
Buried surface area: 1005.53 Å2
Dissociation area: 331.47 Å2
Dissociation energy (ΔGdiss): -7.88 kcal/mol
Dissociation entropy (TΔSdiss): 3.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169567
Assembly 3
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 7497.19 Å2
Buried surface area: 994.44 Å2
Dissociation area: 330.39 Å2
Dissociation energy (ΔGdiss): -7.15 kcal/mol
Dissociation entropy (TΔSdiss): 3.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169567
Assembly 4
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 7329.9 Å2
Buried surface area: 1053.85 Å2
Dissociation area: 332.67 Å2
Dissociation energy (ΔGdiss): -7.91 kcal/mol
Dissociation entropy (TΔSdiss): 3.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169567
Assembly 5
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 8229.71 Å2
Buried surface area: 291.81 Å2
Dissociation area: 53.27 Å2
Dissociation energy (ΔGdiss): 7.21 kcal/mol
Dissociation entropy (TΔSdiss): 0.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169567
Assembly 6
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 8371.0 Å2
Buried surface area: 165.75 Å2
Dissociation area: 82.87 Å2
Dissociation energy (ΔGdiss): 12.62 kcal/mol
Dissociation entropy (TΔSdiss): 0.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169567
Assembly 7
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 8335.44 Å2
Buried surface area: 727.82 Å2
Dissociation area: 198.65 Å2
Dissociation energy (ΔGdiss): -1.41 kcal/mol
Dissociation entropy (TΔSdiss): 3.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169567
Assembly 8
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 8288.89 Å2
Buried surface area: 528.96 Å2
Dissociation area: 172.15 Å2
Dissociation energy (ΔGdiss): -3.62 kcal/mol
Dissociation entropy (TΔSdiss): 3.76 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169567

Macromolecules

Chains: A, B, C, D, E, F, G, H
Length: 138 amino acids
Theoretical weight: 15.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01469 (Residues: 1-135; Coverage: 100%)
Gene name: FABP5
Pfam: Lipocalin / cytosolic fatty-acid binding protein family
InterPro:
CATH: Lipocalin
PDBe-KB: UniProt Coverage View: Q01469  
1138102030405060708090100110120130
 
50100
UniProt
Q01469
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Sequence conservation
Variants

Search similar proteins