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Crystal Structure of mDia2 NES Peptide in complex with CRM1-Ran-RanBP1

Source organisms:
Biochemical function: protein binding
Biological process: protein transport
Cellular component: cytoplasm

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF08767
Domain description: CRM1 C terminal
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 5uwp contains 1 copy of Pfam domain PF08767 (CRM1 C terminal) in Exportin-1. Showing 1 copy in chain C.

PF18787
Domain description: CRM1 / Exportin repeat 3
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 5uwp contains 1 copy of Pfam domain PF18787 (CRM1 / Exportin repeat 3) in Exportin-1. Showing 1 copy in chain C.

PF18784
Domain description: CRM1 / Exportin repeat 2
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 5uwp contains 1 copy of Pfam domain PF18784 (CRM1 / Exportin repeat 2) in Exportin-1. Showing 1 copy in chain C.

PF18777
Domain description: Chromosome region maintenance or exportin repeat
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 5uwp contains 1 copy of Pfam domain PF18777 (Chromosome region maintenance or exportin repeat) in Exportin-1. Showing 1 copy in chain C.

PF08389
Domain description: Exportin 1-like protein
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 5uwp contains 1 copy of Pfam domain PF08389 (Exportin 1-like protein) in Exportin-1. Showing 1 copy in chain C.

PF03810
Domain description: Importin-beta N-terminal domain
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 5uwp contains 1 copy of Pfam domain PF03810 (Importin-beta N-terminal domain) in Exportin-1. Showing 1 copy in chain C.

PF00638
Domain description: RanBP1 domain
Occurring in:
  1. Ran-specific GTPase-activating protein 1
The deposited structure of PDB entry 5uwp contains 1 copy of Pfam domain PF00638 (RanBP1 domain) in Ran-specific GTPase-activating protein 1. Showing 1 copy in chain B.

PF00071
Domain description: Ras family
Occurring in:
  1. GTP-binding nuclear protein Ran
The deposited structure of PDB entry 5uwp contains 1 copy of Pfam domain PF00071 (Ras family) in GTP-binding nuclear protein Ran. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002041
Domain description: Ran GTPase
Occurring in:
  1. GTP-binding nuclear protein Ran
IPR000156
Domain description: Ran binding domain
Occurring in:
  1. Ran-specific GTPase-activating protein 1
IPR001806
Domain description: Small GTPase
Occurring in:
  1. GTP-binding nuclear protein Ran
IPR014877
Domain description: Exportin-1, C-terminal
Occurring in:
  1. Exportin-1
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. Exportin-1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. GTP-binding nuclear protein Ran
IPR040485
Domain description: Exportin-1, repeat 3
Occurring in:
  1. Exportin-1
IPR041235
Domain description: Exportin-1, repeat 2
Occurring in:
  1. Exportin-1
IPR041123
Domain description: Chromosome region maintenance repeat
Occurring in:
  1. Exportin-1
IPR013598
Domain description: Exportin-1/Importin-beta-like
Occurring in:
  1. Exportin-1
IPR001494
Domain description: Importin-beta, N-terminal domain
Occurring in:
  1. Exportin-1
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Exportin-1
IPR045065
Domain description: Exportin-1/5
Occurring in:
  1. Exportin-1
IPR045256
Domain description: Ran-specific GTPase-activating protein 1, Ran-binding domain
Occurring in:
  1. Ran-specific GTPase-activating protein 1
IPR045255
Domain description: Ran binding protein RanBP1-like
Occurring in:
  1. Ran-specific GTPase-activating protein 1
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Ran-specific GTPase-activating protein 1
IPR005225
Domain description: Small GTP-binding domain
Occurring in:
  1. GTP-binding nuclear protein Ran

Structure domains

CATH CATH domains
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Ran-specific GTPase-activating protein 1
The deposited structure of PDB entry 5uwp contains 1 copy of CATH domain 2.30.29.30 (PH-domain like) in Ran-specific GTPase-activating protein 1. Showing 1 copy in chain B.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. GTP-binding nuclear protein Ran
The deposited structure of PDB entry 5uwp contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in GTP-binding nuclear protein Ran. Showing 1 copy in chain A.

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