› 5v5w

X-ray diffraction
2.72Å resolution

Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges

Released:
DOI: 10.2210/pdb5v5w/pdb
PDB entry 5v5w coloured by chain, front view.
PDB entry 5v5w coloured by chain, side view.
PDB entry 5v5w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.
Gangwar SP, Zhong X, Seshadrinathan S, Chen H, Machius M, Rudenko G
Neuron 94 1132-1141.e4 (2017)
PMID: 28641112

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-185532 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Chain: A
Molecule details ›
Chain: A
Length: 230 amino acids
Theoretical weight: 25.93 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8NFP4 (Residues: 22-237; Coverage: 23%)
Gene names: MAMDC3, MDGA1
Sequence domains: Immunoglobulin domain

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I23
Unit cell:
a: 139.068Å b: 139.068Å c: 139.068Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.256
Expression system: Trichoplusia ni

Quick links

Citations

12 review citations

Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits.
Südhof TC. (2017)
11 more

1 mention without citation

Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.
Gangwar et al. (2017)