› 5v8g

X-ray diffraction
1.2Å resolution

Pekin duck lysozyme isoform I (DEL-I)

Released:
DOI: 10.2210/pdb5v8g/pdb
PDB entry 5v8g coloured by chain, front view.
PDB entry 5v8g coloured by chain, side view.
PDB entry 5v8g coloured by chain, top view.
Source organism: Anas platyrhynchos
Primary publication:
Structural basis of antigen recognition: crystal structure of duck egg lysozyme.
Langley DB, Crossett B, Schofield P, Jackson J, Zeraati M, Maltby D, Christie M, Burnett D, Brink R, Goodnow C, Christ D
Acta Crystallogr D Struct Biol 73 910-920 (2017)
PMID: 29095163

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132930 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysozyme C-1 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.16 KDa
Source organism: Anas platyrhynchos
UniProt:
  • Canonical: P00705 (Residues: 19-145; Coverage: 98%)
Sequence domains: C-type lysozyme/alpha-lactalbumin family
Structure domains: Lysozyme

Ligands and Environments

2 bound ligands:
Ligand SCN 1 x SCN
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 28.2Å b: 65.4Å c: 31.64Å
α: 90° β: 113.24° γ: 90°
R-values:
R R work R free
0.147 0.145 0.18

Quick links

Citations

1 citations in other articles

Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells.
Maeda et al. (2021)

3 mentions without citation

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens.
Burnett et al. (2020)
2 more