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Crystal structure of persulfide dioxygenase-rhodanese fusion protein with rhodanese domain inactivating mutation (C314S) from Burkholderia phytofirmans

Source organism: Paraburkholderia phytofirmans PsJN
Biochemical function: sulfur dioxygenase activity
Biological process: hydrogen sulfide metabolic process
Cellular component: not assigned

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EC 1.13.11.18: Persulfide dioxygenase

Reaction catalysed:
(1a) S-sulfanylglutathione + O(2) = glutathione S-dioxide + H(+)
Systematic name:
S-sulfanylglutathione:oxygen oxidoreductase
Alternative Name(s):
  • Sulfur dioxygenase
  • Sulfur oxygenase
  • Sulfur:oxygen oxidoreductase

EC 2.8.1.1: Thiosulfate sulfurtransferase

Reaction catalysed:
Thiosulfate + cyanide = sulfite + thiocyanate
Systematic name:
Thiosulfate:cyanide sulfurtransferase
Alternative Name(s):
  • Rhodanase
  • Rhodanese
  • Thiosulfate cyanide transsulfurase
  • Thiosulfate thiotransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00581
Domain description: Rhodanese-like domain
Occurring in:
  1. Rhodanese domain-containing protein
The deposited structure of PDB entry 5ve4 contains 3 copies of Pfam domain PF00581 (Rhodanese-like domain) in Rhodanese domain-containing protein. Showing 1 copy in chain A.

PF00753
Domain description: Metallo-beta-lactamase superfamily
Occurring in:
  1. Rhodanese domain-containing protein
The deposited structure of PDB entry 5ve4 contains 3 copies of Pfam domain PF00753 (Metallo-beta-lactamase superfamily) in Rhodanese domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001763
Domain description: Rhodanese-like domain
Occurring in:
  1. Rhodanese domain-containing protein
IPR036873
Domain description: Rhodanese-like domain superfamily
Occurring in:
  1. Rhodanese domain-containing protein
IPR001279
Domain description: Metallo-beta-lactamase
Occurring in:
  1. Rhodanese domain-containing protein
IPR036866
Domain description: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Occurring in:
  1. Rhodanese domain-containing protein
IPR044528
Domain description: Persulfide dioxygenase-like, MBL-fold metallo-hydrolase domain
Occurring in:
  1. Rhodanese domain-containing protein

Structure domains

CATH CATH domains
3.40.250.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Oxidized Rhodanese; domain 1
Homology: Rhodanese-like domain
Occurring in:
  1. Rhodanese domain-containing protein
The deposited structure of PDB entry 5ve4 contains 3 copies of CATH domain 3.40.250.10 (Oxidized Rhodanese; domain 1) in Rhodanese domain-containing protein. Showing 1 copy in chain A.
3.60.15.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Metallo-beta-lactamase; Chain A
Homology: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Occurring in:
  1. Rhodanese domain-containing protein
The deposited structure of PDB entry 5ve4 contains 3 copies of CATH domain 3.60.15.10 (Metallo-beta-lactamase; Chain A) in Rhodanese domain-containing protein. Showing 1 copy in chain A.

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