Function and Biology Details
Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome B-type subunit
- Peptidase T1A, proteasome beta-subunit
- Proteasome component (PCI) domain
- Proteasome beta-type subunit, conserved site
- Proteasome alpha-type subunit
- Proteasome alpha-subunit, N-terminal domain
42 more domains
Structure analysis Details
Assembly composition:
hetero 46-mer (preferred)
Assembly name:
20S proteasome complex and Proteasome complex (preferred)
PDBe Complex ID:
PDB-CPX-126182 (preferred)
Entry contents:
32 distinct polypeptide molecules
Macromolecules (32 distinct):
26S proteasome non-ATPase regulatory subunit 1
Molecule details ›
Chain: U
Length: 911 amino acids
Theoretical weight: 101.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 911 amino acids
Theoretical weight: 101.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q99460 (Residues: 7-917; Coverage: 96%)
Sequence domains:
26S proteasome non-ATPase regulatory subunit 3
Molecule details ›
Chain: V
Length: 480 amino acids
Theoretical weight: 54.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 480 amino acids
Theoretical weight: 54.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: O43242 (Residues: 18-497; Coverage: 90%)
Sequence domains:
26S proteasome non-ATPase regulatory subunit 12
26S proteasome non-ATPase regulatory subunit 11
26S proteasome non-ATPase regulatory subunit 6
26S proteasome non-ATPase regulatory subunit 7
26S proteasome non-ATPase regulatory subunit 13
26S proteasome non-ATPase regulatory subunit 4
26S proteasome non-ATPase regulatory subunit 14
26S proteasome non-ATPase regulatory subunit 8
26S proteasome complex subunit SEM1
26S proteasome regulatory subunit 7
26S proteasome regulatory subunit 4
26S proteasome regulatory subunit 8
26S proteasome regulatory subunit 6B
26S proteasome regulatory subunit 10B
26S proteasome regulatory subunit 6A
Proteasome subunit alpha type-6
Proteasome subunit alpha type-2
Proteasome subunit alpha type-4
Proteasome subunit alpha type-7
Proteasome subunit alpha type-5
Proteasome subunit alpha type-1
Proteasome subunit alpha type-3
Proteasome subunit beta type-6
Proteasome subunit beta type-7
Proteasome subunit beta type-3
Proteasome subunit beta type-2
Proteasome subunit beta type-5
Proteasome subunit beta type-1
Proteasome subunit beta type-4
26S proteasome non-ATPase regulatory subunit 2
