› 5vh7

Solution NMR

Structure and dynamics of RNA repeat expansions that cause Huntington's Disease and myotonic dystrophy type 1

Released:
DOI: 10.2210/pdb5vh7/pdb
PDB entry 5vh7 coloured by chain, ensemble of 20 models, front view.
PDB entry 5vh7 coloured by chain, ensemble of 20 models, side view.
PDB entry 5vh7 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.
Chen JL, VanEtten DM, Fountain MA, Yildirim I, Disney MD
Biochemistry 56 3463-3474 (2017)
PMID: 28617590

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197006 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (5'-R(*GP*AP*CP*CP*AP*GP*CP*AP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 15 nucleotides
Theoretical weight: 4.83 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 15%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

1 review citation

RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview.
Šponer et al. (2018)
7 other articles

3 mentions without citation

CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration.
Peng et al. (2021)
2 more